Effect of calorie restriction on the metabolic history of chronologically aging yeast

Alexander A. Goldberg, Simon D. Bourque, Pavlo Kyryakov, +10

Experimental Gerontology

BiologyEnergy MetabolismAgingHealth SciencesLongevity +10

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

Alexander A. Goldberg, Vincent R. Richard, Pavlo Kyryakov, +10

Aging

Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells

Alexander A. Goldberg, Adam Beach, Gerald F. Davies, +3

Oncotarget

Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells

Alexander A. Goldberg, Vladimir I. Titorenko, Adam Beach, +1

PeerJ

Chemoprevention StrategyApoptosisCell DeathOxidative StressBile Acid +14

Caloric Restriction Extends Yeast Chronological Lifespan by Altering a Pattern of Age-Related Changes in Trehalose Concentration

Pavlo Kyryakov, Adam Beach, Vincent R. Richard, +4

Frontiers in Physiology

Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis

Vincent R. Richard, Anna Leonov, Adam Beach, +12

Aging

A novel function of lipid droplets in regulating longevity

Alexander A. Goldberg, Simon D. Bourque, Pavlo Kyryakov, +8

Biochemical Society Transactions

BiologyDynamic OrganellesLongevity RegulationLifespan ExtensionAnti-aging +11

Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan

Michelle T. Burstein, Pavlo Kyryakov, Adam Beach, +7

Cell Cycle

Anti-agingAgingCell CycleBiogerontologyChronological Aging +18

Integration of peroxisomes into an endomembrane system that governs cellular aging

Adam Beach, Michelle T. Burstein, Vincent R. Richard, +3

Frontiers in Physiology

AgingLipid PeroxidationMolecular BiologyRedox BiologyOxidative Stress +16

Mitochondrial membrane lipidome defines yeast longevity

Adam Beach, Vincent R. Richard, Anna Leonov, +7

Aging