Ginger Wu

Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

John S. Sack, Kevin Kish, Chihuei Wang et al. · Proceedings of the National Academy of Sciences · 2001 · 485 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo

Timothy B. Durham, James L. Toth, Valentine J. Klimkowski et al. · Journal of Biological Chemistry · 2015 · 51 citations · Full text

Life Sciences, Biochemistry, Endocrinology +14

Discovery of 5-Chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1<i>H</i>)-one (BMS-903452), an Antidiabetic Clinical Candidate Targeting GPR119

Dean A. Wacker, Ying Wang, Matthias Broekema et al. · Journal of Medicinal Chemistry · 2014 · 46 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Discovery of ( <i>R</i> )-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1- <i>a</i> ]isoindol- 6(2 <i>H</i> )-one, a Selective, Orally Active Agonist of the 5-HT _2C Receptor

Dean A. Wacker, Jeffrey Varnes, Sarah E. Malmstrom et al. · Journal of Medicinal Chemistry · 2007 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents

Saleem Ahmad, Khehyong Ngu, Keith J. Miller et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 20 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11