APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

Yuan-Ta Lin, Jinsoo Seo, Fan Gao, +18

Neuron

Cellular Alterations AssociatedNeurodegenerative DiseasesNeurobiology Of DiseaseMolecular NeuroscienceAlzheimer's Disease +12

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

Waseem Raja, Alison E. Mungenast, Yuan-Ta Lin, +4

PLoS ONE

Cerebral OrganoidNeurochemical BiomarkersAmyloid Precursor ProteinStem Cell BiologyTau Protein +20

APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

Joel Blanchard, Leyla Anne Akay, José Dávila-Velderrain, +25

Nature

OxysterolPhysiologyDegenerative PathologyNeurologyCholesterol Dysregulation +4

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

Joel Blanchard, Michael Bula, José Dávila-Velderrain, +12

Nature Medicine

Human Blood–brain BarrierBlood–brain BarrierImmunologyHematologyVitro Reveals +8

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

Jinsoo Seo, Oleg Kritskiy, L. Ashley Watson, +14

Journal of Neuroscience

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior

Alexi Nott, Jemmie Cheng, Fan Gao, +9

Nature Neuroscience

Histone Deacetylase 3ChromatinTranscriptional RegulationSystems BiologyChromatin Structure +10

Cloning and Analysis of the Alternative Oxidase Gene of <i>Neurospora crassa</i>

Qiuhong Li, R. Gary Ritzel, Lesley L T McLean, +4

Genetics

GeneticsMolecular GeneticsAod-1 MrnaRedox BiologyOxidative Stress +16

A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations

Lev Litichevskiy, Ryan Peckner, Jennifer G. Abelin, +31

Cell Systems

Down-syndrome-induced senescence disrupts the nuclear architecture of neural progenitors

Hiruy S. Meharena, Asaf Marco, Vishnu Dileep, +11

Cell stem cell

Human-Induced Pluripotent Stem Cells Produced Under Xeno-Free Conditions

Pablo J. Ross, Steven T. Suhr, Ramón María Alvargonzález Rodríguez, +5

Stem Cells and Development

Adult Stem CellCell CultureBiomedical EngineeringXeno-free IpscsEmbryology +15