Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation <i>in vitro</i>

John Fisher, Michael J. Rogers, J. M. Halasy, +7

Proceedings of the National Academy of Sciences

SclerostinBone ResorptionMacrophage ApoptosisAlendronate MechanismOsteoporosis +15

Association of mitogen-activated protein kinase with the microtubule cytoskeleton.

A A Reszka, Rony Seger, C D Diltz, +2

Proceedings of the National Academy of Sciences

Mapk ActivitiesCell DeathCytoskeletonCell CycleCellular Physiology +14

M-CSF, TNFα and RANK ligand promote osteoclast survival by signaling through mTOR/S6 kinase

Helmut Glantschnig, John Fisher, Gregg Wesolowski, +2

Cell Death and Differentiation

Signal TransductionPromote Osteoclast SurvivalCell DeathBone HomeostasisMtor/s6 Kinase +5

Identification of amino acid sequences in the integrin beta 1 cytoplasmic domain implicated in cytoskeletal association

A A Reszka, Yusuke Hayashi, AF Horwitz

The Journal of Cell Biology

Cytoskeletal AssociationAmino AcidsCell AdhesionImmunologyMolecular Biology +20

Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells.

Yusuke Hayashi, Beatrice Haimovich, A A Reszka, +2

The Journal of Cell Biology

Immunocytochemical TechniqueLaboratory ImmunologyImmunologyAntigen ProcessingCytoskeleton +17

Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.

Rony Seger, Dalia Seger, A A Reszka, +7

Journal of Biological Chemistry

GeneticsCell ProliferationNih 3T3Signaling PathwayCell Regulation +17

Inhibition of bone resorption by alendronate and risedronate does not require osteoclast apoptosis

Judit Halasy-Nagy, Gideon A. Rodan, A A Reszka

Bone

Bone ResorptionMedicineOsteoarthritisOsteoporosisPharmacology +6

Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol/lipoproteins

Eva Luegmayr, Helmut Glantschnig, Gregg Wesolowski, +4

Cell Death and Differentiation

Developmental BiologyBone Morphogenic ProteinOsteoclast FormationBone MetabolismMedicine +5

Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions.

A A Reszka, J. Chloä Bulinski, E G Krebs, +1

Molecular Biology of the Cell

Microtubule-specific InteractionsMolecular BiologyCytoskeletonCell GrowthChemotactic Cell Migration +18

Chimeric Integrins Expressed in Retinal Ganglion Cells Impair Process Outgrowth in Vivo

Alain Lilienbaum, A A Reszka, Alan F. Horwitz, +1

Molecular and Cellular Neuroscience

Ganglion CellPhotoreceptor CellSignal TransductionRetinaOphthalmology +6