Concepedia

Machiko Irie

MI

8

Publications

482

Citations

8

H-Index

2008

Active since

Affiliations

Kyoto Institute of Technology(Current)

Chugai Pharma (United States)

The University of Osaka

Machiko Irie is an author at Kyoto Institute of Technology specializing in medicine, biochemistry, and natural sciences.

Top concepts

Publications per year

2008–2023

8

Publications

8

Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor

Mikimasa Tanada, Minoru Tamiya, Atsushi Matsuo et al. · Journal of the American Chemical Society · 2023 · 132 citations

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases

Taku Fukuzawa, Zenjiro Sampei, Kenta Haraya et al. · Scientific Reports · 2017 · 104 citations · Full text

, , +17

Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets

Atsushi Ohta, Mikimasa Tanada, Shojiro Shinohara et al. · Journal of the American Chemical Society · 2023 · 86 citations

Crystal structure of the halotolerant γ‐glutamyltranspeptidase from <i>Bacillus subtilis</i> in complex with glutamate reveals a unique architecture of the solvent‐exposed catalytic pocket

Kei Wada, Machiko Irie, Hideyuki Suzuki et al. · FEBS Journal · 2010 · 58 citations

, , +14

Crystal Structures of γ-Glutamyltranspeptidase in Complex with Azaserine and Acivicin: Novel Mechanistic Implication for Inhibition by Glutamine Antagonists

Kei Wada, Jun Hiratake, Machiko Irie et al. · Journal of Molecular Biology · 2008 · 47 citations

, , +6

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