Joanna Sinclair

Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector

H. Bobby Gaspar, Kathryn L. Parsley, Steven J. Howe et al. · The Lancet · 2004 · 684 citations

Medicine, Immunology, Molecular Genetics +17

Successful Reconstitution of Immunity in ADA-SCID by Stem Cell Gene Therapy Following Cessation of PEG-ADA and Use of Mild Preconditioning

H. Bobby Gaspar, Emma Bjorkegren, Kate Parsley et al. · Molecular Therapy · 2006 · 218 citations · Full text

Medicine, Hematology, Immunology +17

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

Kerstin Schwarzwaelder, Steven J. Howe, Manfred Schmidt et al. · Journal of Clinical Investigation · 2007 · 204 citations · Full text

Life Sciences, Genetics, Immunology +13

Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cells

Fang Zhang, Susannah I. Thornhill, Steven J. Howe et al. · Blood · 2007 · 177 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Failure of SCID-X1 gene therapy in older patients

Adrian J. Thrasher, Salima Hacein‐Bey‐Abina, H. Bobby Gaspar et al. · Blood · 2005 · 128 citations · Full text

Medicine, Genetics, Geriatric Medicine +6