Avi Patel

Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids

Samuel Obeng, Shyam H. Kamble, Morgan E. Reeves et al. · Journal of Medicinal Chemistry · 2019 · 158 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats

Samuel Obeng, Jenny L. Wilkerson, Francisco León et al. · Journal of Pharmacology and Experimental Therapeutics · 2020 · 102 citations · Full text

Medicine, Pharmacology, Molecular Pharmacology +14

Activity of <i>Mitragyna speciosa</i> (“Kratom”) Alkaloids at Serotonin Receptors

Francisco León, Samuel Obeng, Marco Mottinelli et al. · Journal of Medicinal Chemistry · 2021 · 83 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Exploring the Chemistry of Alkaloids from Malaysian <i>Mitragyna speciosa</i> (Kratom) and the Role of Oxindoles on Human Opioid Receptors

Nelson Jeng‐Yeou Chear, Francisco León, Abhisheak Sharma et al. · Journal of Natural Products · 2021 · 79 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Interactive Effects of µ-Opioid and Adrenergic-α2 Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine

Samuel Obeng, Francisco León, Avi Patel et al. · Journal of Pharmacology and Experimental Therapeutics · 2022 · 42 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16