Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats

Samuel Obeng, Jenny L. Wilkerson, Francisco León, +17

Journal of Pharmacology and Experimental Therapeutics

Activity of <i>Mitragyna speciosa</i> (“Kratom”) Alkaloids at Serotonin Receptors

Francisco León, Samuel Obeng, Marco Mottinelli, +14

Journal of Medicinal Chemistry

Directed Biosynthesis of Mitragynine Stereoisomers

Carsten Schotte, Yindi Jiang, Dagny Grzech, +7

Journal of the American Chemical Society

Efficient preparation of an N-aryl β-amino acid via asymmetric hydrogenation and direct asymmetric reductive amination en route to Ezetimibe

Guuske F. Busscher, Laurent Lefort, Jozef G.O. Cremers, +9

Tetrahedron Asymmetry

EngineeringBiochemistryN-aryl β-Amino AcidOrganic ChemistryEfficient Preparation +5

Characterization of Sigma 1 Receptor Antagonist CM-304 and Its Analog, AZ-66: Novel Therapeutics Against Allodynia and Induced Pain

Thomas J. Cirino, Shainnel O. Eans, Jéssica Medina, +5

Frontiers in Pharmacology

Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5

Carlotta Granchi, Sarabindu Roy, Marco Mottinelli, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural SciencesBiocatalysisSulfonamide-containing N-hydroxyindole-2-carboxylates +3

The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study

Erin C. Berthold, Shyam H. Kamble, Raju S. Kanumuri, +11

Drug Metabolism and Disposition

Characterization of CM-398, a Novel Selective Sigma-2 Receptor Ligand, as a Potential Therapeutic for Neuropathic Pain

Lisa Wilson, Amy R. Alleyne, Shainnel O. Eans, +6

Molecules

Metabolism of Speciociliatine, an Overlooked Kratom Alkaloid for its Potential Pharmacological Effects

Shyam H. Kamble, Erin C. Berthold, Raju S. Kanumuri, +7

The AAPS Journal

Potential Pharmacological EffectsPharmacological StudyBiochemistryMedicinePhysiology +6

Divergent Cytotoxic and Metabolically Stimulative Functions of Sigma-2 Receptors: Structure-Activity Relationships of 6-Acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79) Derivatives

Hilary E. Nicholson, Walid Alsharif, Anthony B. Comeau, +5

Journal of Pharmacology and Experimental Therapeutics