Afshan Ahmed

Human CHCHD4 mitochondrial proteins regulate cellular oxygen consumption rate and metabolism and provide a critical role in hypoxia signaling and tumor progression

Jun Yang, Oliver Staples, Luke W. Thomas et al. · Journal of Clinical Investigation · 2012 · 93 citations · Full text

Life Sciences, Biology, Molecular Biology +17

Small-Molecule Activation of p53 Blocks Hypoxia-Inducible Factor 1α and Vascular Endothelial Growth Factor Expression In Vivo and Leads to Tumor Cell Apoptosis in Normoxia and Hypoxia

Jun Yang, Afshan Ahmed, Evon Poon et al. · Molecular and Cellular Biology · 2009 · 85 citations · Full text

Life Sciences, Cancer Biology, Oncology +17

Osimertinib, an Irreversible Next-Generation EGFR Tyrosine Kinase Inhibitor, Exerts Antitumor Activity in Various Preclinical NSCLC Models Harboring the Uncommon EGFR Mutations G719X or L861Q or S768I

Nicolas Floc’h, Sangbin Lim, Sue Bickerton et al. · Molecular Cancer Therapeutics · 2020 · 49 citations · Full text

Medicine, Oncology, Pharmacology +17

CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain

Luke W. Thomas, Jenna M. Stephen, Cinzia Esposito et al. · Cancer & Metabolism · 2019 · 22 citations · Full text

Life Sciences, Molecular Biology, Oncology +17

Diminished Macrophage Apoptosis and Reactive Oxygen Species Generation after Phorbol Ester Stimulation in Crohn's Disease

Christine D. Palmer, Farooq Rahman, Gavin W. Sewell et al. · PLoS ONE · 2009 · 21 citations · Full text

Life Sciences, Immunology, Pathology +17