Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

Imran Siddiqui, Karin Schaeuble, Vijaykumar Chennupati, +10

Immunity

Tumor ImmunologyCheckpoint Blockade ImmunotherapyCancer ImmunosurveillanceImmunologyImmune Checkpoint Inhibitor +5

Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence

João F. Passos, Gabriele Saretzki, Shaheda Ahmed, +10

PLoS Biology

Role of Reduced Lipoic Acid in the Redox Regulation of Mitochondrial Aldehyde Dehydrogenase (ALDH-2) Activity

Philip Wenzel, Ulrich Hink, Matthias Oelze, +8

Journal of Biological Chemistry

Redox RegulationNitric OxideLipid PeroxidationReduced Lipoic AcidRedox Biology +19

Essential role of CCL21 in establishment of central self-tolerance in T cells

Mina Kozai, Yuki Kubo, Tomoya Katakai, +7

The Journal of Experimental Medicine

Central Self-toleranceLymphocyte DevelopmentT-regulatory CellImmunologyImmune Regulation +18

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

Hsin-Ying Huang, Ana Rivas-Caicedo, François Renevey, +13

Proceedings of the National Academy of Sciences

Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration

Mark A. Hauser, Karin Schaeuble, Ilona Kindinger, +5

Immunity

InflammationCytokineSignal TransductionMolecular PathwayCell Trafficking +10

Lymphatic vessel density is associated with CD8⁺ T cell infiltration and immunosuppressive factors in human melanoma

Natacha Bordry, Maria A.S. Broggi, Kaat de Jonge, +19

OncoImmunology

Distinct motifs in the chemokine receptor CCR7 regulate signal transduction, receptor trafficking and chemotaxis

Carolina Otero, Petra Eisele, Karin Schaeuble, +2

Journal of Cell Science

ImmunologyCellular PhysiologyDistinct MotifsSignaling PathwayCell Regulation +15

Cross-Talk Between TCR and CCR7 Signaling Sets a Temporal Threshold for Enhanced T Lymphocyte Migration

Karin Schaeuble, Mark A. Hauser, Eva Singer, +2

The Journal of Immunology

Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration

Karin Schaeuble, Mark A. Hauser, Alexandra Rippl, +4

Journal of Cell Science