Yan-Fa Yu

Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors

Yi‐You Huang, Yan-Fa Yu, Chen Zhang et al. · Journal of Medicinal Chemistry · 2019 · 53 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16

Discovery and Optimization of Chromeno[2,3-<i>c</i>]pyrrol-9(2<i>H</i>)-ones as Novel Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension

Deyan Wu, Tianhua Zhang, Yiping Chen et al. · Journal of Medicinal Chemistry · 2017 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of Novel Pyrazolopyrimidinone Derivatives as Phosphodiesterase 9A Inhibitors Capable of Inhibiting Butyrylcholinesterase for Treatment of Alzheimer’s Disease

Yan-Fa Yu, Ya-Dan Huang, Chen Zhang et al. · ACS Chemical Neuroscience · 2017 · 40 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors

Xu-Nian Wu, Ya-Dan Huang, Jinxuan Li et al. · Acta Pharmaceutica Sinica B · 2018 · 23 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia

Yinuo Wu, Qian Zhou, Tianhua Zhang et al. · Journal of Medicinal Chemistry · 2019 · 22 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17