Ya-Dan Huang

Discovery and Optimization of Chromeno[2,3-<i>c</i>]pyrrol-9(2<i>H</i>)-ones as Novel Selective and Orally Bioavailable Phosphodiesterase 5 Inhibitors for the Treatment of Pulmonary Arterial Hypertension

Deyan Wu, Tianhua Zhang, Yiping Chen et al. · Journal of Medicinal Chemistry · 2017 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of Novel Pyrazolopyrimidinone Derivatives as Phosphodiesterase 9A Inhibitors Capable of Inhibiting Butyrylcholinesterase for Treatment of Alzheimer’s Disease

Yan-Fa Yu, Ya-Dan Huang, Chen Zhang et al. · ACS Chemical Neuroscience · 2017 · 40 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Design, Synthesis, and Biological Evaluation of Dual-Target Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 9A (PDE9A) for the Treatment of Alzheimer’s Disease

Jinhui Hu, Ya-Dan Huang, Tingting Pan et al. · ACS Chemical Neuroscience · 2018 · 30 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease

Chen Zhang, Qian Zhou, Xu-Nian Wu et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 2017 · 28 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Optimization of Chromeno[2,3-<i>c</i>]pyrrol-9(2<i>H</i>)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure–Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension

Deyan Wu, Ya-Dan Huang, Yiping Chen et al. · Journal of Medicinal Chemistry · 2018 · 28 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17