Xu-Nian Wu

A novel inhibitor of N6-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities

Guoyou Xie, Xu-Nian Wu, Yu‐Yi Ling et al. · Acta Pharmaceutica Sinica B · 2021 · 85 citations · Full text

Discovery of Novel Pyrazolopyrimidinone Derivatives as Phosphodiesterase 9A Inhibitors Capable of Inhibiting Butyrylcholinesterase for Treatment of Alzheimer’s Disease

Yan-Fa Yu, Ya-Dan Huang, Chen Zhang et al. · ACS Chemical Neuroscience · 2017 · 39 citations

Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease

Chen Zhang, Qian Zhou, Xu-Nian Wu et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 2017 · 28 citations · Full text

Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors

Xu-Nian Wu, Ya-Dan Huang, Jinxuan Li et al. · Acta Pharmaceutica Sinica B · 2018 · 23 citations · Full text

Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia

Xu-Nian Wu, Qian Zhou, Ya-Dan Huang et al. · Acta Pharmaceutica Sinica B · 2022 · 19 citations · Full text