Conrad L. Cowan

A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine

Scott M. DeWire, Dennis S. Yamashita, David H. Rominger et al. · Journal of Pharmacology and Experimental Therapeutics · 2013 · 655 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation

Diane Gesty‐Palmer, Minyong Chen, Éric Reiter et al. · Journal of Biological Chemistry · 2006 · 466 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Structure–Activity Relationships and Discovery of a G Protein Biased μ Opioid Receptor Ligand, [(3-Methoxythiophen-2-yl)methyl]({2-[(9<i>R</i>)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the Treatment of Acute Severe Pain

Xiaotao Chen, Philip Pitis, Guodong Liu et al. · Journal of Medicinal Chemistry · 2013 · 203 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

First Clinical Experience With TRV130: Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

David G. Soergel, Ruth Ann Subach, Brian M. Sadler et al. · The Journal of Clinical Pharmacology · 2013 · 126 citations

Medicine, Clinical Pharmacokinetics, Pharmacology +15

Enhanced role of potassium channels in relaxations to acetylcholine in hypercholesterolemic rabbit carotid artery

Soheil Najibi, Conrad L. Cowan, James Palacino et al. · American Journal of Physiology-Heart and Circulatory Physiology · 1994 · 126 citations

Medicine, Cardiology, Pharmacology +17