Sondra H. Berger

Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells.

Sondra H. Berger, Chung‐Her Jenh, Lee F. Johnson et al. · Molecular Pharmacology · 1985 · 155 citations

Life Sciences, Genetics, Molecular Biology +8

Human Thymidylate Synthase Is in the Closed Conformation When Complexed with dUMP and Raltitrexed, an Antifolate Drug^,

Jason Phan, Sangita Koli, W. Minor et al. · Biochemistry · 2001 · 111 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Relationship of dUMP and free FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil.

Sondra H. Berger, Maire Hakala · Molecular Pharmacology · 1984 · 83 citations

Life Sciences, Biochemistry, Cell Biology +9

Structure of Human Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors

Jason Phan, David Steadman, Sangita Koli et al. · Journal of Biological Chemistry · 2001 · 77 citations · Full text

Life Sciences, Biochemistry, Oncology +16

A naturally occurring variation in thymidylate synthase structure is associated with a reduced response to 5-fluoro-2'-deoxyuridine in a human colon tumor cell line.

Sondra H. Berger, Karen W. Barbour, François Berger · Molecular Pharmacology · 1988 · 59 citations

Medicine, Oncology, Pharmacology +15