UK-37,248, A novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity

Michael J. Randall, M. J. PARRY, Edward Hawkeswood, +2

Thrombosis Research

ThrombopoiesisThrombosisBlood PlateletMedicineA Novel +8

A Potent, Selective Inhibitor of Matrix Metalloproteinase-3 for the Topical Treatment of Chronic Dermal Ulcers

M. Jonathan Fray, Roger P. Dickinson, John P. Huggins, +1

Journal of Medicinal Chemistry

Collagen MatrixImmunologyChronic Dermal UlcersPathologyCell Death +17

Novel antifungal 2-aryl-1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives with high activity against Aspergillus fumigatus

Roger P. Dickinson, Andrew Bell, Christopher A. Hitchcock, +4

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAntifungal AgentAntifungal AgentsMedicineButan-2-ol Derivatives +4

Selective Urokinase-Type Plasminogen Activator Inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines

Paul V. Fish, Chris Barber, David G. Brown, +12

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceCompound 26Biochemistry +11

The design and synthesis of a novel series of indole derived selective ETA antagonists

David J. Rawson, Kevin N. Dack, Roger P. Dickinson, +1

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryNovel SeriesBiochemistryNatural Sciences +8

Cerebrovasodilatation through selective inhibition of the enzyme carbonic anhydrase. 2. Imidazo[2,1-b]thiadiazole and imidazo[2,1-b]thiazolesulfonamides

I. T. Barnish, Peter E. Cross, Roger P. Dickinson, +4

Journal of Medicinal Chemistry

Antiparasitic AgentPharmacotherapyChemical BiologyThrombosisMedicinal Chemistry +15

Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles

Peter E. Cross, Roger P. Dickinson, M. J. PARRY, +1

Journal of Medicinal Chemistry

Carboxyl CarbonMolecular PharmacologyMedicinal ChemistryBiochemistryTxa2 Synthetase +11

Electrophysiologic Properties of UK-66,914, a Novel Class III Antiarrhythmic Agent

Michael Gwilt, H. W. Dalrymple, Roger A. Burges, +4

Journal of Cardiovascular Pharmacology

Cardiac MuscleHeart FailureCardiovascular PharmacologyEffective Refractory PeriodElectrophysiological Evaluation +15

Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 3: 1-Isoquinolinylguanidines

Chris Barber, Roger P. Dickinson, Paul V. Fish

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineMechanism Of ActionPharmacotherapyPharmacology +3

Selective urokinase-type plasminogen activator (uPA) inhibitors. Part 1: 2-Pyridinylguanidines

Chris Barber, Roger P. Dickinson, Valerie A. Horne

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineMechanism Of ActionPharmacotherapyPharmacology +3