Benjamin G. Tehan

Discovery of 1,2,4-Triazine Derivatives as Adenosine A_2A Antagonists using Structure Based Drug Design

Miles Congreve, Stephen P. Andrews, A.S. Dore et al. · Journal of Medicinal Chemistry · 2012 · 301 citations · Full text

Combinatorial Chemistry, Compound 4K, Pharmacotherapy +16

Structural insight into allosteric modulation of protease-activated receptor 2

R.K. Cheng, Cédric Fiez-Vandal, Oliver Schlenker et al. · Nature · 2017 · 246 citations

Signal Transduction, Biochemistry, G Protein-coupled Receptor +6

Biophysical Fragment Screening of the β ₁ -Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug Design

J.A. Christopher, Jason Brown, A.S. Dore et al. · Journal of Medicinal Chemistry · 2013 · 157 citations · Full text

Fragment and Structure-Based Drug Discovery for a Class C GPCR: Discovery of the mGlu ₅ Negative Allosteric Modulator HTL14242 (3-Chloro-5-[6-(5-fluoropyridin-2-yl)pyrimidin-4-yl]benzonitrile)

J.A. Christopher, Sarah J. Aves, K.A. Bennett et al. · Journal of Medicinal Chemistry · 2015 · 156 citations · Full text

Estimation of pKa Using Semiempirical Molecular Orbital Methods. Part 1: Application to Phenols and Carboxylic Acids.

Benjamin G. Tehan, Edward J. Lloyd, Margaret G. Wong et al. · Quantitative Structure-Activity Relationships · 2002 · 120 citations

Carboxylic Acids, Engineering, Chemical Analysis +15