Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

Taku Saito, Atsushi Fukai, Akihiko Mabuchi, +11

Nature Medicine

Transcriptional RegulationMusculoskeletal ResearchDevelopmental BiologyBone Morphogenic ProteinOsteoarthritis +7

Excessive mechanical loading promotes osteoarthritis through the gremlin-1–NF-κB pathway

Song Ho Chang, Daisuke Mori, Hiroshi Kobayashi, +14

Nature Communications

Nitridation process of sapphire substrate surface and its effect on the growth of GaN

Kazushige Uchida, A. Watanabe, Fumiko Yano, +3

Journal of Applied Physics

Materials ScienceAluminium NitrideThick Gan LayerSapphire Substrate SurfaceEngineering +12

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes

Makoto Hirata, Fumitaka Kugimiya, Atsushi Fukai, +13

Human Molecular Genetics

Bone RepairOrthopaedic SurgeryMusculoskeletal ResearchRegenerative MedicineInflammation +16

Involvement of Endogenous Bone Morphogenetic Protein (BMP) 2 and BMP6 in Bone Formation

Fumitaka Kugimiya, Hiroshi Kawaguchi, Satoru Kamekura, +9

Journal of Biological Chemistry

SclerostinDevelopmental BiologyEndogenous Bmp2Orthopaedic SurgeryBone Morphogenic Protein +11

The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner

Fumiko Yano, Fumitaka Kugimiya, Shinsuke Ohba, +8

Biochemical and Biophysical Research Communications

Musculoskeletal ResearchDevelopmental BiologyBone Morphogenic ProteinSox9-dependent MannerMedicine +4

Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage

Ryosuke Echigo, Nobuyuki Shimohata, K. Karatsu, +11

Journal of Translational Medicine

Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

Hiroshi Kobayashi, Song Ho Chang, Daisuke Mori, +12

Nature Communications

Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2

Shurei Sugita, Yoko Hosaka, Keita Okada, +17

Proceedings of the National Academy of Sciences

Runx1 and Runx2 cooperate during sternal morphogenesis

Ayako Kimura, Hiroyuki Inose, Fumiko Yano, +16

Development

Regenerative MedicineKnockout MouseDevelopmental BiologyBone Morphogenic ProteinDevelopmental Genetics +11