Hiroshi Kawaguchi

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations

Knockout Mouse, Mendelian Disorder, Aging +8

OARSI guidelines for the non-surgical management of knee osteoarthritis

T.E. McAlindon, Raveendhara R. Bannuru, Matthew C. Sullivan et al. · Osteoarthritis and Cartilage · 2014 · 3K citations · Full text

Suppression of Aging in Mice by the Hormone Klotho

Hiroshi Kurosu, Masaya Yamamoto, Jeremy D. Clark et al. · Science · 2005 · 1.9K citations · Full text

Lifespan Extension, Insulin Signaling, Molecular Physiology +15

Prevalence of knee osteoarthritis, lumbar spondylosis, and osteoporosis in Japanese men and women: the research on osteoarthritis/osteoporosis against disability study

Noriko Yoshimura, Shigeyuki Muraki, Hiroyuki Oka et al. · Journal of Bone and Mineral Metabolism · 2009 · 807 citations

Bone Disease, Rheumatology, Spondyloarthritis +10

PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

Toru Akune, Shinsuke Ohba, Satoru Kamekura et al. · Journal of Clinical Investigation · 2004 · 784 citations