Jessica Mancuso

ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials

Roberto A. Calle, Neeta B. Amin, Santos Carvajal‐Gonzalez et al. · Nature Medicine · 2021 · 207 citations

Obesity, Metabolic Syndrome, Dgat2 Inhibitor +12

Clinical trial of an inhibitor of RAGE-Aβ interactions in Alzheimer disease

Douglas Galasko, J. Simon Bell, Jessica Mancuso et al. · Neurology · 2014 · 178 citations · Full text

Efficacy and Safety of PF‐06651600 (Ritlecitinib), a Novel JAK3/TEC Inhibitor, in Patients With Moderate‐to‐Severe Rheumatoid Arthritis and an Inadequate Response to Methotrexate

Michael F. Robinson, Nemanja Damjanov, Bojana Stamenković et al. · Arthritis & Rheumatology · 2020 · 84 citations · Full text

Thorough QT Study with Recommended and Supratherapeutic Doses of Tolterodine

Bimal Malhotra, Paul Glue, Kevin Sweeney et al. · Clinical Pharmacology & Therapeutics · 2007 · 80 citations

Drug Safety, Therapeutic Drug Monitoring, Qtc Effects +9

Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1 <i>H</i> -pyrazolo-[3,4- <i>b</i> ]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator

Lei Zhang, Gayatri Balan, Gabriela Barreiro et al. · Journal of Medicinal Chemistry · 2014 · 51 citations · Full text