Jinzhi Tan

pH-dependent Conformational Flexibility of the SARS-CoV Main Proteinase (Mpro) Dimer: Molecular Dynamics Simulations and Multiple X-ray Structure Analyses

Jinzhi Tan, Koen H. G. Verschueren, K. Anand et al. · Journal of Molecular Biology · 2005 · 202 citations · Full text

Ph-dependent Conformational Flexibility, Protein Assembly, Biomolecular Structure Prediction +12

The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes

Jinzhi Tan, Clemens Vonrhein, Oliver S. Smart et al. · PLoS Pathogens · 2009 · 177 citations · Full text

A G-quadruplex-binding macrodomain within the “SARS-unique domain” is essential for the activity of the SARS-coronavirus replication–transcription complex

Yuri Kusov, Jinzhi Tan, Enrique Alarcón Álvarez et al. · Virology · 2015 · 135 citations

Virus Structure, Viral Replication, Medicine +9

3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

Jinzhi Tan, Shyla George, Yuri Kusov et al. · Journal of Virology · 2013 · 116 citations · Full text

Crystal Structure, Cleavage Specificity, Viral Polymerase Structure +19

Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization

Lili Chen, Jinzhi Tan, Jing Chen et al. · Journal of Biological Chemistry · 2004 · 108 citations · Full text