pH-dependent Conformational Flexibility of the SARS-CoV Main Proteinase (Mpro) Dimer: Molecular Dynamics Simulations and Multiple X-ray Structure Analyses

Jinzhi Tan, Koen H. G. Verschueren, K. Anand, +11

Journal of Molecular Biology

Ph-dependent Conformational FlexibilityProtein AssemblyBiomolecular Structure PredictionProtein FoldingNatural Sciences +10

The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes

Jinzhi Tan, Clemens Vonrhein, Oliver S. Smart, +7

PLoS Pathogens

A G-quadruplex-binding macrodomain within the “SARS-unique domain” is essential for the activity of the SARS-coronavirus replication–transcription complex

Yuri Kusov, Jinzhi Tan, Enrique Alarcón Álvarez, +2

Virology

Virus StructureViral ReplicationMedicineViral Polymerase MechanismMolecular Biology +7

3C Protease of Enterovirus 68: Structure-Based Design of Michael Acceptor Inhibitors and Their Broad-Spectrum Antiviral Effects against Picornaviruses

Jinzhi Tan, Shyla George, Yuri Kusov, +9

Journal of Virology

Crystal StructureCleavage SpecificityViral Polymerase StructureMolecular BiologyAntiviral Drug +17

Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization

Lili Chen, Jinzhi Tan, Jing Chen, +6

Journal of Biological Chemistry

Sensitized Detection of Inhibitory Fragments and Iterative Development of Non‐Peptidic Protease Inhibitors by Dynamic Ligation Screening

Marco F. Schmidt, Albert Isidro‐Llobet, Michael Lisurek, +4

Angewandte Chemie International Edition

Drug TargetSensitized DetectionMolecular BiologyProteomic TechnologyMedicinal Chemistry +14

The “SARS-unique domain” (SUD) of SARS coronavirus is an oligo(G)-binding protein

Jinzhi Tan, Yuri Kusov, D. Mutschall, +4

Biochemical and Biophysical Research Communications

Virus StructureViral PathogenesisMolecular BiologyVirologyViral Structural Protein +5

Structural and Functional Study of d-Glucuronyl C5-epimerase

Yi Qin, Jiyuan Ke, Xin Gu, +12

Journal of Biological Chemistry

Synthesis and antitumor evaluation of novel 5-substituted-4-hydroxy-8-nitroquinazolines as EGFR signaling-targeted inhibitors

Yi Jin, Huiyuan Li, Liping Lin, +4

Bioorganic & Medicinal Chemistry

Medicinal ChemistryEgfr Signaling-targeted InhibitorsNovel 5-Substituted-4-hydroxy-8-nitroquinazolinesPharmacologyPharmacological Agent +8

Design, synthesis and antitumor evaluation of a new series of N-substituted-thiourea derivatives

Jian Li, Jinzhi Tan, Lili Chen, +11

Acta Pharmacologica Sinica

Medicinal ChemistryDerivative (Chemistry)Bioorganic ChemistryDerivativesNatural Sciences +10