Janet Sim

Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation

Jing Lü, Tatiana Zavorotinskaya, Yumin Dai et al. · Blood · 2013 · 161 citations · Full text

Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5-<i>a</i>]pyrazines as ATR Inhibitors

Paul A. Barsanti, Robert J. Aversa, Xianming Jin et al. · ACS Medicinal Chemistry Letters · 2014 · 41 citations · Full text

Pharmaceutical Science, Drug Target, Novel Potent +20

Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors

Yipin Lu, Mark Knapp, Kenneth Crawford et al. · Journal of Molecular Biology · 2017 · 40 citations · Full text

Molecular Pharmacology, Pikk Family, Protein Function +15

Identification of Novel Small-Molecule Inhibitors for Human Transketolase by High-Throughput Screening with Fluorescent Intensity (FLINT) Assay

Mark Du, Janet Sim, Lijuan Fang et al. · SLAS DISCOVERY · 2004 · 37 citations · Full text

Mutation of N304 to Leucine in Streptomyces clavuligerus Deacetoxycephalosporin C Synthase Creates an Enzyme with Increased Penicillin Analogue Conversion

Hong Soon Chin, Janet Sim, Tiow Suan Sim · Biochemical and Biophysical Research Communications · 2001 · 33 citations

Biosynthesis, Health Sciences, Biochemistry +7