Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

John S. Tzartos, Manuel A. Friese, Matthew Craner, +4

American Journal Of Pathology

InflammationCytokineAutoimmune DiseaseAllergyMedicine +11

Siponimod versus placebo in secondary progressive multiple sclerosis (EXPAND): a double-blind, randomised, phase 3 study

Ludwig Kappos, Amit Bar‐Or, Bruce Cree, +314

The Lancet

Neurological DisorderClinical NeurologyClinical TrialsSiponimod Versus PlaceboNeurological Monitoring +7

Molecular changes in neurons in multiple sclerosis: Altered axonal expression of Na _v 1.2 and Na _v 1.6 sodium channels and Na ⁺ /Ca ² + exchanger

Matthew Craner, Jia Newcombe, Joel A. Black, +3

Proceedings of the National Academy of Sciences

Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system

Manuel A. Friese, Matthew Craner, Ruth Etzensperger, +5

Nature Medicine

InflammationAutoimmune InflammationAutoimmune DiseaseMedicineImmunology +11

Upregulation of Sodium Channel Na_v1.3 and Functional Involvement in Neuronal Hyperexcitability Associated with Central Neuropathic Pain after Spinal Cord Injury

Bryan C. Hains, Joshua P. Klein, Carl Y. Saab, +3

Journal of Neuroscience

Central Neuropathic PainPeripheral Nerve InjuryPain MedicineNeuropathic PainMolecular Pain +17

Altered Sodium Channel Expression in Second-Order Spinal Sensory Neurons Contributes to Pain after Peripheral Nerve Injury

Bryan C. Hains, Carl Y. Saab, Joshua P. Klein, +2

Journal of Neuroscience

Sodium channels contribute to microglia/macrophage activation and function in EAE and MS

Matthew Craner, Tina G. Damarjian, Shujun Liu, +6

Glia

InflammationSodium Channel BlockersNeurophysiologyMedicineImmunology +12

Changes of sodium channel expression in experimental painful diabetic neuropathy

Matthew Craner, Joshua P. Klein, Muthukrishnan Renganathan, +2

Annals of Neurology

Neuropathic PainMolecular PainPeripheral NervePainful Diabetic NeuropathyCellular Physiology +19

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

Manuel A. Friese, Karen B. Jakobsen, Lone Smidstrup Friis, +8

Nature Medicine

Autoimmune DiseaseMedicineT-regulatory CellHla ImmunogeneticsImmunology +7

Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination

Matthew Craner

Brain

Inflammatory DemyelinationImmunologyNeurotransmissionPeripheral NervePeripheral Nerves +21