Activity of temozolomide in the treatment of central nervous system tumor xenografts.

Henry S. Friedman, M E Dolan, A E Pegg, +5

PubMed

Tumor InnervationPharmacotherapyHigh-grade GliomasGliomaTumor Biology +15

Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.

R. Brian Mitchell, R C Moschel, M E Dolan

PubMed

Tumor BiologyOncologyChemoprevention StrategyGliomaHuman Tumor Xenografts +12

O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.

Laurence D. Rhines, Prakash Sampath, M E Dolan, +3

PubMed

Intracranial Rat GliomaPharmacotherapyHigh-grade GliomasBiomedical EngineeringExperimental Pharmacology +17

Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft.

V J Patel, Gertrude B. Elion, Peter J. Houghton, +6

PubMed

Schedule-dependent ActivityNeuro-oncologyMedicinal ChemistryTumor InnervationAdditive Activity +12

Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-BIS(2-chloroethyl)-1-nitrosourea(BCNU)

M E Dolan, Anthony E. Pegg, Robert C. Moschel, +1

Biochemical Pharmacology

Tumor BiologyOncologyMedicinePathologyColorectal Cancer +4

Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan.

Howard S. Frıedman, M E Dolan, Scott H. Kaufmann, +6

PubMed

PathologyPharmacotherapyTreatment ResistanceTumor BiologyDna Polymerase Delta +18

Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N′-bis(2-chloroethyl)-N-nitrosourea

Anthony E. Pegg, Kristin Swenn, Mi-Young Chae, +2

Biochemical Pharmacology

OncologyMedicinePharmacologyCancer Cell BiologyMolecular Oncology +8

Production of antibodies to peptide sequences present in human <i>O</i>⁶-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts

Anthony E. Pegg, Laurie Wiest, Christine Mummert, +1

Carcinogenesis

Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.

Upendra K. Marathi, M E Dolan, L C Erickson

PubMed

Tumor BiologyOncologyO6-methylguanine-dna Methyltransferase ActivityBiochemistryMgmt Activity +13

Debenzylation of O6-benzyl-8-oxoguanine in human liver: implications for O6-benzylguanine metabolism

Lina Long, Robert C. Moschel, M E Dolan

Biochemical Pharmacology

BiochemistryMedicineLiver PhysiologyHepatotoxicityO6-benzylguanine Metabolism +9