Menglan Yuan

Aging renders the brain vulnerable to amyloid β-protein neurotoxicity

Changiz Guela, Chuang-Kuo Wu, Daniel Saroff et al. · Nature Medicine · 1998 · 528 citations

Neurodegenerative Diseases, Alzheimer's Disease, β-Protein Neurotoxicity +8

Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1

Zhuohua Zhang, Philip M. Nadeau, Weihong Song et al. · Nature Cell Biology · 2000 · 409 citations

Protein Secretion, Protein Function, Signal Transduction +9

Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

Jorge Busciglio, Alejandra Pelsman, Caine W. Wong et al. · Neuron · 2002 · 390 citations · Full text

Down Syndrome, Alzheimer's Disease, Mitochondrial Function +10

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

Weihong Song, Philip M. Nadeau, Menglan Yuan et al. · Proceedings of the National Academy of Sciences · 1999 · 362 citations · Full text

Amyloid β interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease

Alfredo Lorenzo, Menglan Yuan, Zhuohua Zhang et al. · Nature Neuroscience · 2000 · 257 citations

Amyloid β, Neurodegenerative Diseases, Alzheimer's Disease +10