Abrogation of Bronchial Eosinophilic Inflammation and Airway Hyperreactivity in Signal Transducers and Activators of Transcription (STAT)6-deficient Mice

Toshihiko Akimoto, Fumio Numata, M. Tamura, +5

The Journal of Experimental Medicine

ICAM-1-dependent pathway is critically involved in the pathogenesis of adjuvant arthritis in rats

Yutaka Iigo, Tohru Takashi, Takuya Tamatani, +5

The Journal of Immunology

RP58 Associates with Condensed Chromatin and Mediates a Sequence-specific Transcriptional Repression

Katsunori Aoki, Gaoyuan Meng, Kenji Suzuki, +5

Journal of Biological Chemistry

Sequence and expression of rat ICAM-1

Yasuo Kita, Tohru Takashi, Yutaka Iigo, +3

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Knockout MouseSignal TransductionMolecular PhysiologyImmunologyRat Icam-1 +4

The effect of anti-adhesion molecule antibody on the development of collagen-induced arthritis

Kiichi Kakimoto, Takashi Nakamura, Koji Ishii, +5

Cellular Immunology

InflammationRheumatologyRheumatoid DisorderAnti-adhesion Molecule AntibodyAllergy +12

Constitutive expression of ICAM-1 in rat microvascular systems analyzed by laser confocal microscopy

Yutaka Iigo, Makoto Suematsu, Toshiaki Higashida, +6

American Journal of Physiology-Heart and Circulatory Physiology

Immunocytochemical TechniqueCell AdhesionImmunologyCytoskeletonBiomedical Engineering +19

Affinity and Kinetic Analysis of the Molecular Interaction of ICAM-1 and Leukocyte Function-Associated Antigen-1

Yuichi Tominaga, Yasuo Kita, Atsushi Satoh, +5

The Journal of Immunology

Proteinlipid InteractionCell AdhesionImmunologyImmunologic MechanismAntigen Processing +20

Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists

Jun Chiba, Gensuke Takayama, Tohru Takashi, +11

Bioorganic & Medicinal Chemistry

Vla-4 AntagonistsMedicinal ChemistryPharmaceutical ScienceBiochemistryMedicine +6

Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA‐1 clustering and cell adhesion of activated lymphocytes

Junji Endo, Noriko Toyama‐Sorimachi, Choji Taya, +8

FEBS Letters

Discovery of <i>trans</i>-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4<i>S</i>)-methoxy-(2<i>S</i>)-pyrrolidinylmethoxy]cyclohexanecarboxylic Acid: An Orally Active, Selective Very Late Antigen-4 Antagonist

Fumihito Muro, Shin Iimura, Yuuichi Sugimoto, +13

Journal of Medicinal Chemistry

Pharmaceutical ScienceImmunologyOrally ActivePeptide ScienceImmunotherapeutics +17