Abrogation of Bronchial Eosinophilic Inflammation and Airway Hyperreactivity in Signal Transducers and Activators of Transcription (STAT)6-deficient Mice

Toshihiko Akimoto, Fumio Numata, M. Tamura, +5

The Journal of Experimental Medicine

Involvement of Tyrosine Kinase-2 in Both the IL-12/Th1 and IL-23/Th17 Axes In Vivo

Masayuki Ishizaki, Toshihiko Akimoto, Ryuta Muromoto, +7

The Journal of Immunology

T-regulatory CellImmunologyImmune RegulationDermatologyImmune System +18

Tyk2 is a therapeutic target for psoriasis-like skin inflammation

Masayuki Ishizaki, Ryuta Muromoto, Toshihiko Akimoto, +8

International Immunology

InflammationIl-22 Signal TransductionJak Kinase FamilyAutoimmune DiseaseTyrosine Kinase 2 +10

Lipopolysaccharide accelerates collagen‐induced arthritis in association with rapid and continuous production of inflammatory mediators and anti‐type <scp>II</scp> collagen antibody

Shinji Tanaka, Tadashi Toki, Toshihiko Akimoto, +1

Microbiology and Immunology

In Vitro Maintenance of Terminal‐Differentiated State in Hepatocytes Entrapped Within Calcium Alginate

Yoshiharu Miura, Toshihiko Akimoto, Yuko Fuke, +2

Artificial Organs

Discovery of imidazo[1,2-b]pyridazine derivatives as IKKβ inhibitors. Part 1: Hit-to-lead study and structure–activity relationship

H. Shimizu, Shinji Tanaka, Tadashi Toki, +6

Bioorganic & Medicinal Chemistry Letters

Structure–activity RelationshipMedicinal ChemistryBiochemistryMedicineNatural Sciences +8

Characterization of cereblon-dependent targeted protein degrader by visualizing the spatiotemporal ternary complex formation in cells

Tomohiro Kaji, Hiroshi Koga, Mutsumi Kuroha, +2

Scientific Reports

Involvement of NF- B in TGF- -mediated suppression of IL-4 signaling

Tetsuya Yamamoto, Seiyu Imoto, Yuichi Sekine, +4

Biochemical and Biophysical Research Communications

InflammationCytokineAutoimmune DiseaseImmune Cell DevelopmentT-regulatory Cell +11

Effect of combined administration of a synthetic low-toxicity lipid A derivative, DT-5461a, and indomethacin in various experimental tumor models of colon 26 carcinoma in mice

Takeshi Jimbo, Toshihiko Akimoto, Akiko Tohgo

Cancer Immunology Immunotherapy

Tumor BiologyColon 26Combined AdministrationMedicinePharmacology +8

Antitumor effect of DT-5461a, a synthetic low-toxicity lipid a analog, involves endogenous tumor necrosis factor induction subsequent to macrophage activation

Toshihiko Akimoto, Eiji Kumazawa, Takeshi Jimbo, +2

International Journal of Immunopharmacology

InflammationAnti-inflammatoryMedicineApoptosisImmunology +7