IgH class switching and translocations use a robust non-classical end-joining pathway

Catherine T. Yan, Cristian Boboilă, Ellen Kris Souza, +9

Nature

Igh Class SwitchingMolecular BiologySystems Biology

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

Craig H. Bassing, Katrin F. Chua, JoAnn Sekiguchi, +11

Proceedings of the National Academy of Sciences

H2AX Prevents DNA Breaks from Progressing to Chromosome Breaks and Translocations

Sonia Franco, Monica Gostissa, Shan Zha, +13

Molecular Cell

ChromatinGenome InstabilityChromatin RemodelingGeneticsMolecular Biology +6

Distinct Roles of Chromatin-Associated Proteins MDC1 and 53BP1 in Mammalian Double-Strand Break Repair

Anyong Xie, Andrea J. Hartlerode, Manuel Stucki, +9

Molecular Cell

ChromatinGenome InstabilityDna DamageChromatin StructureChromatin Remodeling +9

Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70

Cristian Boboilă, Mila Janković, Catherine T. Yan, +8

Proceedings of the National Academy of Sciences

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

Cristian Boboilă, Catherine T. Yan, Duane R. Wesemann, +6

The Journal of Experimental Medicine

ChromatinGenome InstabilityNatural SciencesImmunologyOligonucleotide +13

Mechanisms promoting translocations in editing and switching peripheral B cells

Jing Wang, Monica Gostissa, Catherine T. Yan, +9

Nature

Developmental BiologySignal TransductionCell InteractionCell TraffickingCell Migration +5

XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice

Catherine T. Yan, Dhruv Kaushal, Michael Murphy, +17

Proceedings of the National Academy of Sciences

Recurrent TranslocationsKnockout MouseGenome InstabilityDevelopmental BiologyMedicine +11

Long-range oncogenic activation of Igh–c-myc translocations by the Igh 3′ regulatory region

Monica Gostissa, Catherine T. Yan, Julia M. Bianco, +3

Nature

Transcriptional RegulationSignal TransductionCell RegulationIgh–c-myc TranslocationsOncogenic Agent +10

Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching

Jing Wang, Frederick W. Alt, Monica Gostissa, +7

The Journal of Experimental Medicine