Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains

Toshimitsu Niwa, Naohito Takeda, Hideo Yoshizumi, +5

Biochemical and Biophysical Research Communications

MedicineNeuropharmacologyNeurochemical BiomarkersNeurologyNeuroscience +5

Presence of tetrahydroisoquinoline, a parkinsonism-related compound, in foods

Toshimitsu Niwa, Hideo Yoshizumi, Akira Tatematsu, +2

Journal of Chromatography B Biomedical Sciences and Applications

Parkinsonism-related CompoundFood Bioactive CompoundMedicineParkinson DiseaseNeurology +2

RNA metabolism in uremic patients: Accumulation of modified ribonucleosides in uremic serum

Toshimitsu Niwa, Naohito Takeda, Hideo Yoshizumi

Kidney International

UrologyRna MetabolismRenal FunctionBiochemistryMedicine +8

Novel Nitric Oxide and Superoxide Generation Inhibitors, Persenone A and B, from Avocado Fruit

Oe Kyung Kim, Akira Murakami, Yoshimasa Nakamura, +3

Journal of Agricultural and Food Chemistry

Elevated Serum Levels of 3-Deoxyglucosone, a Potent Protein-Cross-Linking Intermediate of the Maillard Reaction, in Uremic Patients

Toshimitsu Niwa, Naohito Takeda, Takashi Miyazaki, +6

˜The œNephron journals/Nephron journals

Healthy SubjectsGlycobiologyMaillard ReactionOxidative StressMetabolic Syndrome +14

Mass spectra of some alkyl isoxazoles

Mamoru Ohashi, Hajime Kamachi, Hiroshi Kakisawa, +4

Organic Mass Spectrometry

EngineeringHeterocyclicBiochemistryRelated IsoxazolesNatural Sciences +9

Detection of tetrahydroisoquinoline in parkinsonian brain as an endogenous amine by use of gas chromatography-mass spectrometry

Toshimitsu Niwa, Naohito Takeda, Toshikuni Sasaoka, +5

Journal of Chromatography B Biomedical Sciences and Applications

Endogenous AmineMedicineNeuropharmacologyNeurochemical BiomarkersAnalytical Chemistry +8

The primary fragmentation step of isoxazole upon electron impact. A correlation with photochemistry

Hisao Nakata, Hiroshi Sakurai, Hideo Yoshizumi, +1

Organic Mass Spectrometry

EngineeringOrganic ChemistryChemistryHeterocycle ChemistryIsomeric Radical Ions +16

Metabolic studies on the nigrostriatal toxin MPTP and its MAO B generated dihydropyridinium metabolite MPDP+

Toshihiro Shinka, Patricia Caldera-Munoz, Hideo Yoshizumi, +2

Chemical Research in Toxicology

Endogenous synthesis of N-methylsalsolinol, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, in rat brain during in vivo microdialysis with salsolinol, as demonstrated by gas chromatography—mass spectrometry

Toshimitsu Niwa, Wakako Maruyama, Daiichiro Nakahara, +7

Journal of Chromatography B Biomedical Sciences and Applications

Pharmacological StudyBiochemistryMedicineVivo MicrodialysisNeuropharmacology +7