Concepedia

Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains

Toshimitsu Niwa, Naohito Takeda, Hideo Yoshizumi, Akira Tatematsu, Mitsuo Yoshida, P. Dostert, Makoto Naoi, Toshiharu Nagatsu

Biochemical and Biophysical Research Communications · 1991 · 96 citations · 21 references

DOI

Concepts

References

21

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

J. William Langston, Philip L. Ballard, James W. Tetrud et al. · Science · 1983 · 4.9K citations

, , +14

Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in Mice

Richard E. Heikkila, Arthur Hess, Roger C. Duvoisin · Science · 1984 · 1K citations

, , +17

Tetrahydroisoquinoline Alkaloids: in vivo Metabolites of L-Dopa in Man

M. Sandler, Susan Bonham Carter, K.R. Hunter et al. · Nature · 1973 · 367 citations

, , +14

An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions

Toshiharu Nagatsu, Mitsuo Yoshida · Neuroscience Letters · 1988 · 198 citations

, , +17

Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in Parkinsonian and normal human brains

Toshimitsu Niwa, Naohito Takeda, Norio Kaneda et al. · Biochemical and Biophysical Research Communications · 1987 · 185 citations

, , +8