Antitumor bisdioxopiperazines inhibit yeast DNAtopoisomerase II by trapping the enzyme in the form of a closed proteinclamp.

Joaquím Roca, Ryoji Ishida, James M. Berger, +2

Proceedings of the National Academy of Sciences

Molecular BiologyAntimicrobial ChemotherapyType Ii DnaChemical BiologyDrug Resistance +16

Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives.

K Tanabe, Yoji Ikegami, Ryoji Ishida, +1

PubMed

Molecular PharmacologyMedicinal ChemistryPharmaceutical ChemistryHealth SciencesAntiparasitic Agent +12

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

T Andoh, Kazuyuki Ishii, Yoshio Suzuki, +4

Proceedings of the National Academy of Sciences

ChromatinGenome InstabilityOncogenic AgentNatural SciencesRpmi 8402 +12

Inhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events.

Ryoji Ishida, Makoto Sato, Tetsuharu Narita, +5

The Journal of Cell Biology

CytogeneticsGeneticsMolecular BiologyMolecular GeneticsCell Cycle +19

Supercoiled DNA folded by non-histone proteins in cultured mammalian cells

Toshinori Ide, Masaki Nakane, Kaijiro Anzai, +1

Nature

ChromatinChromatin StructureChromatin RemodelingNatural SciencesEpigenetic Change +7

Characterization of a camptothecin-resistant human DNA topoisomerase I.

Eigil Kjeldsen, Bjarne J. Bonven, T Andoh, +4

Journal of Biological Chemistry

BiochemistryWild TypeNatural SciencesDna AnalysisOligonucleotide +7

Rapid purification and characterization of DNA topoisomerase I from cultured mouse mammary carcinoma FM3A cells.

Kazuyuki Ishii, Takayuki Hasegawa, Kouichi Fujisawa, +1

Journal of Biological Chemistry

Rapid PurificationMolecular BiologyCancer BiologyEnzyme-heparin InteractionTumor Biology +16

Suppressor gene Su3+ of E. coli, a structural gene for tyrosine TRNA.

T Andoh, Haruo Ozeki

Proceedings of the National Academy of Sciences

Human immunodeficiency virus type 1 reverse transcriptase: enhancement of activity by interaction with cellular topoisomerase I.

Hirokazu Takahashi, Michiyuki Matsuda, Asato Kojima, +5

Proceedings of the National Academy of Sciences

Viral ReplicationImmunologyMolecular BiologyHiv-1 Gag ProteinsCellular Topo +16

Quantitative detection of hepatitis C virus RNA by multicyclic RT-PCR

Narihiro Ishiyama, Kazuhiko Katayama, Norikuni Ishimi, +7

International Hepatology Communications

Diagnostic VirologyHepatitis CViral DiagnosticsViral HepatitisHepatitis +6