Mary K. Joseph

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

Tilman Oltersdorf, Steven W. Elmore, Alexander R. Shoemaker et al. · Nature · 2005 · 3.4K citations

Medicine, Molecular Biology, Oncology +14

Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL

Milan Bruncko, Thorsten Oost, Barbara Belli et al. · Journal of Medicinal Chemistry · 2007 · 295 citations · Full text

Pharmacy, Oncology, Pharmacology +14

Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-x _L from NMR and Parallel Synthesis

Andrew M. Petros, Jürgen Dinges, David J. Augeri et al. · Journal of Medicinal Chemistry · 2005 · 293 citations

Medicine, Medicinal Chemistry, Pharmacology +14

A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic Drugs <i>In vitro</i> and <i>In vivo</i>

Alex R. Shoemaker, Anatol Oleksijew, Joy Bauch et al. · Cancer Research · 2006 · 146 citations

Medicine, Oncology, Pharmacology +10

Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo

Michael Wendt, Shen Wang, Aaron Kunzer et al. · Journal of Medicinal Chemistry · 2006 · 131 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17