Structure−Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061

Montse Llinàs‐Brunet, Murray D. Bailey, Gordon T. Bolger, +14

Journal of Medicinal Chemistry

Competitive Hexapeptide InhibitorsPharmacotherapyAntiviral DrugPharmaceutical ChemistryDrug Resistance +14

A Systematic Approach to the Optimization of Substrate-Based Inhibitors of the Hepatitis C Virus NS3 Protease:  Discovery of Potent and Specific Tripeptide Inhibitors

Montse Llinàs‐Brunet, Murray D. Bailey, Élise Ghiro, +5

Journal of Medicinal Chemistry

Peptide SubstratesAntiviral DrugChemical BiologyCompetitive Peptide InhibitorsMedicinal Chemistry +19

Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors

Montse Llinàs‐Brunet, Murray D. Bailey, Gulrez Fazal, +11

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineAntiviral Drug DevelopmentHighly PotentHepatitis +7

Synthesis of BILN 2061, an HCV NS3 Protease Inhibitor with Proven Antiviral Effect in Humans

Anne‐Marie Faucher, Murray D. Bailey, Pierre L. Beaulieu, +11

Organic Letters

Medicinal ChemistryNs3 Protease InhibitorMedicineImmunologyAntiviral Drug Development +11

Discovery of a Potent and Selective Noncovalent Linear Inhibitor of the Hepatitis C Virus NS3 Protease (BI 201335)

Montse Llinàs‐Brunet, Murray D. Bailey, Nathalie Goudreau, +16

Journal of Medicinal Chemistry

Solid-Phase Synthesis of Peptidomimetic Inhibitors for the Hepatitis C Virus NS3 Protease

Marc‐André Poupart, Dale R. Cameron, Catherine Chabot, +5

The Journal of Organic Chemistry

Ns3 Protease EnzymeHepatitis C VirusMolecular BiologyAntiviral DrugChemical Biology +14

Ligands for the Tyrosine Kinase p56<i>^lck</i> SH2 Domain:  Discovery of Potent Dipeptide Derivatives with Monocharged, Nonhydrolyzable Phosphate Replacements

Pierre L. Beaulieu, Dale R. Cameron, Jean‐Marie Ferland, +21

Journal of Medicinal Chemistry

Molecular BiologySignal Transduction EventsPotent DipeptideReceptor Tyrosine KinaseSrc Family +15

Peptidomimetic Inhibitors of Herpes Simplex Virus Ribonucleotide Reductase with Improved <i>in Vivo</i> Antiviral Activity

Neil Moss, Pierre L. Beaulieu, Jean‐Simon Duceppe, +15

Journal of Medicinal Chemistry

Role of .sigma.-Donation in the Stereocontrol of Hydrogen-Transfer Reactions Involving Acyclic Radicals

Yvan Guindon, Abdelmalik Slassi, Jean Rancourt, +5

The Journal of Organic Chemistry

EngineeringChemical AnalysisProton-coupled Electron TransferAltmetric Attention ScoreOrganic Chemistry +14

Cyclopropanation in vinyl radical cyclizations: The importance of structural constraints.

Réal C. Denis, Jean Rancourt, Élise Ghiro, +2

Tetrahedron Letters

EngineeringHeterocyclicRadical (Chemistry)Organic ChemistryStructural Constraints +2