Robert J. Lutz

Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody–Cytotoxic Drug Conjugate

Gail D. Lewis Phillips, Guangmin Li, Debra L. Dugger et al. · Cancer Research · 2008 · 1.6K citations

Drug Targeting, Breast Oncology, Disulfide Linkers +12

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome<i>c</i>release in isolated mitochondria

Masashi Narita, Shigeomi Shimizu, Toshinori Ito et al. · Proceedings of the National Academy of Sciences · 1998 · 923 citations · Full text

Induction of apoptosis by the Bcl-2 homologue Bak

Thomas W. Chittenden, Elizabeth A. Harrington, Rosemary O’Connor et al. · Nature · 1995 · 734 citations

Signal Transduction, Bcl-2 Homologue Bak, Cell Regulation +6

Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing

Hans K. Erickson, Peter U. Park, Wayne C. Widdison et al. · Cancer Research · 2006 · 566 citations · Full text

Immunology, Immunotherapy, Cancer Biology +19

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

Thomas W. Chittenden, Cathy Flemington, Anne B. Houghton et al. · The EMBO Journal · 1995 · 490 citations · Full text

Protein Function, Signal Transduction, Signaling Pathway +10