Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody–Cytotoxic Drug Conjugate

Gail D. Lewis Phillips, Guangmin Li, Debra L. Dugger, +14

Cancer Research

Drug TargetingBreast OncologyDisulfide LinkersMedicineImmunology +10

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome<i>c</i>release in isolated mitochondria

Masashi Narita, Shigeomi Shimizu, Toshinori Ito, +4

Proceedings of the National Academy of Sciences

Induction of apoptosis by the Bcl-2 homologue Bak

Thomas W. Chittenden, Elizabeth A. Harrington, Rosemary O’Connor, +4

Nature

Signal TransductionBcl-2 Homologue BakCell RegulationReceptor Tyrosine KinaseApoptosis +4

Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing

Hans K. Erickson, Peter U. Park, Wayne C. Widdison, +6

Cancer Research

ImmunologyImmunotherapyCancer BiologyTumor BiologyMedicinal Chemistry +17

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

Thomas W. Chittenden, Cathy Flemington, Anne B. Houghton, +4

The EMBO Journal

Protein FunctionSignal TransductionSignaling PathwayCell RegulationConserved Domain +8

Expression of <i>bbc3</i> , a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

Jiawen Han, Cathy Flemington, Anne B. Houghton, +5

Proceedings of the National Academy of Sciences

ApoptosisImmunologyCell DeathCell Death MechanismsTumor Biology +19

A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2

Victor S. Goldmacher, Laura M. Bartle, Anna Skaletskaya, +10

Proceedings of the National Academy of Sciences

Molecular VirologyMitochondrial FunctionApoptosisImmunologyViral Pathogenesis +13

Semisynthetic Maytansine Analogues for the Targeted Treatment of Cancer

Wayne C. Widdison, Sharon Wilhelm, Emily E. Cavanagh, +11

Journal of Medicinal Chemistry

NanomedicineMedicinal ChemistrySemisynthetic Maytansine AnaloguesOncologyChain Length +10

Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance

Yelena Kovtun, Charlene A. Audette, Michele Mayo, +16

Cancer Research

ImmunologyImmunotherapyTumor BiologySynthetic ImmunologyDrug Resistance +16

Bak BH3 Peptides Antagonize Bcl-xL Function and Induce Apoptosis through Cytochrome c-independent Activation of Caspases

Eric P. Holinger, Thomas W. Chittenden, Robert J. Lutz

Journal of Biological Chemistry

Cytochrome C-independent ActivationBcl-2 Homology 3Protein FunctionSignal TransductionSignaling Pathway +13