The Leptin-Deficient (<i>ob/ob</i>) Mouse

Viktor R. Drel, Nazar Mashtalir, Olga Ilnytska, +4

Diabetes

Peripheral NerveAdipokinesSynaptic SignalingInsulin SignalingMetabolic Syndrome +18

Dietary methionine restriction enhances metabolic flexibility and increases uncoupled respiration in both fed and fasted states

Barbara E. Hasek, Laura K. Stewart, Tara M. Henagan, +10

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

NutritionDietary MrCaloric RestrictionObesityMetabolic Syndrome +17

Alternative mRNA Splicing Produces a Novel Biologically Active Short Isoform of PGC-1α

Yubin Zhang, Peter Huypens, Aaron W. Adamson, +10

Journal of Biological Chemistry

Remodeling the Integration of Lipid Metabolism Between Liver and Adipose Tissue by Dietary Methionine Restriction in Rats

Barbara E. Hasek, Anik Boudreau, Jeho Shin, +10

Diabetes

Fatty Liver DiseaseCaloric RestrictionObesityMetabolic SyndromeBody Composition +17

Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis.

Viktor R. Drel, Pál Pacher, Tayyeba K. Ali, +4

PubMed

Ocular DiseaseFidarestat TreatmentOxidative StressMetabolic SyndromeDiabetic Retinopathy +15

NT-PGC-1α Protein Is Sufficient to Link β3-Adrenergic Receptor Activation to Transcriptional and Physiological Components of Adaptive Thermogenesis

Ji Suk Chang, Vivian E. Fernand, Yubin Zhang, +4

Journal of Biological Chemistry

Truncated ProteinMolecular RegulationNt-pgc-1α ProteinCellular PhysiologyMetabolic Syndrome +22

Poly(ADP-Ribose)Polymerase Inhibition Counteracts Cataract Formation and Early Retinal Changes in Streptozotocin-Diabetic Rats

Viktor R. Drel, Weizheng Xu, Jie Zhang, +7

Investigative Ophthalmology & Visual Science

Leptin‐deficient (ob/ob) mouse‐ a new animal model of peripheral neuropathy of Type 2 diabetes and obesity

Viktor R. Drel, Nazar Mashtalir, Olga Ilnytska, +4

The FASEB Journal

Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis

Viktor R. Drel, Pál Pacher, Tayyeba K. Ali, +4

International Journal of Molecular Medicine

Ocular DiseaseFidarestat TreatmentCell DeathRetinal TherapiesOcular Surface Physiology +19

Regulation of Brown and White Adipocyte Transcriptome by the Transcriptional Coactivator NT-PGC-1α

Ji-Hyun Kim, Vivian E. Fernand, Tara M. Henagan, +5

PLoS ONE

Molecular RegulationMitochondrial BiologyMetabolic RemodelingTranscriptional RegulationMitochondrial Biogenesis +19