Activity-Evoked Capacitative Ca²⁺Entry: Implications in Synaptic Plasticity

Atsushi Baba, Takuya Yasui, Shigeyoshi Fujisawa, +5

Journal of Neuroscience

LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models

Rina Baba, Satoru Matsuda, Yuuichi Arakawa, +11

Science Advances

Long-Range Axonal Calcium Sweep Induces Axon Retraction

Ryuji Yamada, Takuya Sasaki, Junya Ichikawa, +3

Journal of Neuroscience

NeurotransmitterIntracellular Calcium DynamicsAxon RetractionCytoskeletonMechanotransduction +15

TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats

Hiroe Hara, Atsushi Suzuki, Akiyoshi Kunugi, +3

Pharmacology Biochemistry and Behavior

Minimal Agonistic ActivityPsychotropic MedicationPsychopharmacologyPharmacotherapyExperimental Pharmacology +22

cAMP Differentially Regulates Axonal and Dendritic Development of Dentate Granule Cells

Ryuji Yamada, Norio Matsuki, Yuji Ikegaya

Journal of Biological Chemistry

Synaptic TransmissionNeurotransmitterCytoskeletonNeurite PolarityNeurotransmission +21

Cryopreservation of Granule Cells From the Postnatal Rat Hippocampus

Junya Ichikawa, Ryuji Yamada, Rieko Muramatsu, +3

Journal of Pharmacological Sciences

Discovery of Benzofuran Derivatives that Collaborate with Insulin-Like Growth Factor 1 (IGF-1) to Promote Neuroprotection

Takeshi Wakabayashi, Norihito Tokunaga, Kazuyuki Tokumaru, +7

Journal of Medicinal Chemistry

Evaluation of fibroblast growth factor activity exerted by placental extract used as a cosmetic ingredient

Kouhei Ito, Ryuji Yamada, Nobuki Matsumoto, +1

Journal of Cosmetic Dermatology

Therapeutic potential of TAK-071, a muscarinic M1 receptor positive allosteric modulator with low cooperativity, for the treatment of cognitive deficits and negative symptoms associated with schizophrenia

Emi Kurimoto, Ryuji Yamada, Takeshi Hirakawa, +1

Neuroscience Letters

TAK-861, a potent, orally available orexin receptor 2-selective agonist, produces wakefulness in monkeys and improves narcolepsy-like phenotypes in mouse models

Kayo Mitsukawa, Michiko Terada, Ryuji Yamada, +7

Scientific Reports