Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP)

Hitoshi Hashimoto, Norihito Shintani, Kazuhiro Tanaka, +13

Proceedings of the National Academy of Sciences

NeurotransmitterSocial SciencesPituitary GlandNeuroendocrine MechanismPacap Gene +15

Possible involvement of a cyclic AMP-dependent mechanism in PACAP-induced proliferation and ERK activation in astrocytes

Hitoshi Hashimoto, Akiyoshi Kunugi, Naohisa Arakawa, +8

Biochemical and Biophysical Research Communications

Signal TransductionMolecular PhysiologySignaling PathwayCell RegulationMedicine +10

TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window

Akiyoshi Kunugi, Maiko Tanaka, Atsushi Suzuki, +11

Neuropsychopharmacology

Molecular PharmacologyLittle Agonistic EffectPharmacologyAmpa-r PotentiatorMechanism Of Action +6

HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production

Akiyoshi Kunugi, Yasukazu Tajima, Haruhiko Kuno, +2

Journal of Pharmacology and Experimental Therapeutics

TAK-137, an AMPA receptor potentiator with little agonistic effect, produces antidepressant-like effect without causing psychotomimetic effects in rats

Atsushi Suzuki, Koji Murakami, Yasukazu Tajima, +3

Pharmacology Biochemistry and Behavior

Psychoactive DrugLittle Agonistic EffectPsychiatryMedicineAntidepressant-like Effect +10

Preclinical characterization of AMPA receptor potentiator TAK‐137 as a therapeutic drug for schizophrenia

Maiko Tanaka, Akiyoshi Kunugi, Atsushi Suzuki, +3

Pharmacology Research & Perspectives

TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats

Hiroe Hara, Atsushi Suzuki, Akiyoshi Kunugi, +3

Pharmacology Biochemistry and Behavior

Minimal Agonistic ActivityPsychotropic MedicationPsychopharmacologyPharmacotherapyExperimental Pharmacology +22

Desensitization, surface expression, and glycosylation of a functional, epitope-tagged type I PACAP (PAC1) receptor

Norihito Shintani, Hitoshi Hashimoto, Akiyoshi Kunugi, +6

Biochimica et Biophysica Acta (BBA) - Biomembranes

Epitope-tagged TypeSignal TransductionMolecular PhysiologyG Protein-coupled ReceptorMedicine +8

Mislocalization of Nucleocytoplasmic Transport Proteins in Human Huntington’s Disease PSC-Derived Striatal Neurons

Jenny Lange, Alison Wood‐Kaczmar, Aneesa Ali, +9

Frontiers in Cellular Neuroscience

Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement

Atsushi Suzuki, Akiyoshi Kunugi, Yasukazu Tajima, +9

Scientific Reports