ITZ-1, a Client-Selective Hsp90 Inhibitor, Efficiently Induces Heat Shock Factor 1 Activation

Haruhide Kimura, Hiroshi Yukitake, Yasukazu Tajima, +8

Chemistry & Biology

Protein Quality ControlSignal TransductionImmunologyMolecular BiologySystems Biology +3

BTZO-1, a Cardioprotective Agent, Reveals that Macrophage Migration Inhibitory Factor Regulates ARE-Mediated Gene Expression

Haruhide Kimura, Yoshimi Sato, Yasukazu Tajima, +7

Chemistry & Biology

InflammationSignal TransductionSignaling PathwayDisease PathophysiologyCell Signaling +8

TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window

Akiyoshi Kunugi, Maiko Tanaka, Atsushi Suzuki, +11

Neuropsychopharmacology

Molecular PharmacologyLittle Agonistic EffectPharmacologyAmpa-r PotentiatorMechanism Of Action +6

HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production

Akiyoshi Kunugi, Yasukazu Tajima, Haruhiko Kuno, +2

Journal of Pharmacology and Experimental Therapeutics

TAK-137, an AMPA receptor potentiator with little agonistic effect, produces antidepressant-like effect without causing psychotomimetic effects in rats

Atsushi Suzuki, Koji Murakami, Yasukazu Tajima, +3

Pharmacology Biochemistry and Behavior

Psychoactive DrugLittle Agonistic EffectPsychiatryMedicineAntidepressant-like Effect +10

BTZO-15, an ARE-Activator, Ameliorates DSS- and TNBS-Induced Colitis in Rats

Hiroshi Yukitake, Haruhide Kimura, Hirobumi Suzuki, +5

PLoS ONE

InflammationChronic Inflammatory DiseasesAnti-inflammatoryAutoimmune DiseaseBiochemistry +13

The Chondroprotective Agent ITZ-1 Inhibits Interleukin-1β–Induced Matrix Metalloproteinase–13 Production and Suppresses Nitric Oxide–Induced Chondrocyte Death

Haruhide Kimura, Hiroshi Yukitake, Hirobumi Suzuki, +6

Journal of Pharmacological Sciences

TAK-653, an AMPA receptor potentiator with minimal agonistic activity, produces an antidepressant-like effect with a favorable safety profile in rats

Hiroe Hara, Atsushi Suzuki, Akiyoshi Kunugi, +3

Pharmacology Biochemistry and Behavior

Minimal Agonistic ActivityPsychotropic MedicationPsychopharmacologyPharmacotherapyExperimental Pharmacology +22

Strictly regulated agonist-dependent activation of AMPA-R is the key characteristic of TAK-653 for robust synaptic responses and cognitive improvement

Atsushi Suzuki, Akiyoshi Kunugi, Yasukazu Tajima, +9

Scientific Reports

Electrophysiological characterization of a novel AMPA receptor potentiator, TAK-137, in rat hippocampal neurons

Atsushi Suzuki, Yasukazu Tajima, Akiyoshi Kunugi, +1

Neuroscience Letters

Synaptic PlasticityHyperpolarization (Biology)NeurophysiologyMedicineSynaptic Transmission +10