Benzimidazole Derivatives Bearing Substituted Biphenyls as Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase Inhibitors:  Structure−Activity Relationship Studies and Identification of a Potent and Highly Selective Inhibitor JTK-109

Shintaro Hirashima, Takayoshi Suzuki, Tomio Ishida, +6

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryBioorganic ChemistryDerivativesNatural Sciences +13

Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: Identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole

Tomio Ishida, Takayoshi Suzuki, Shintaro Hirashima, +6

Bioorganic & Medicinal Chemistry Letters

BiochemistryMedicineAntiviral Drug DevelopmentAntiviral TherapyHepatitis +6

4-(4-Cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as Selective Cyclooxygenase-2 Inhibitors:  Enhancement of the Selectivity by Introduction of a Fluorine Atom and Identification of a Potent, Highly Selective, and Orally Active COX-2 Inhibitor JTE-522

Hiromasa Hashimoto, Katsuaki Imamura, Jun‐ichi Haruta, +1

Journal of Medicinal Chemistry

Bioorganic ChemistryPharmacotherapySelective Cyclooxygenase-2 InhibitorsPharmaceutical ChemistryMedicinal Chemistry +15

Discovery of Conformationally Constrained Tetracyclic Compounds as Potent Hepatitis C Virus NS5B RNA Polymerase Inhibitors

Kazutaka Ikegashira, Takahiro Oka, Shintaro Hirashima, +12

Journal of Medicinal Chemistry

Combinatorial ChemistryBiochemistryMedicineNatural SciencesAntiviral Drug Development +9

Zwitterionic DNA

Hiromasa Hashimoto, Marek G. Nelson, Christopher Switzer

Journal of the American Chemical Society

EngineeringDatabasesAltmetric Attention ScoreBibliometricsImpact Factor +14

Self-Association of 2',5'-linked deoxynucleotides: meta-DNA

Hiromasa Hashimoto, Christopher Switzer

Journal of the American Chemical Society

Bioorganic ChemistryEngineeringGeneticsDna AnalysisAltmetric Attention Score +16

SAR Exploration Guided by LE and Fsp ³ : Discovery of a Selective and Orally Efficacious RORγ Inhibitor

Kazuyuki Hirata, Masayuki Kotoku, Noriyoshi Seki, +29

ACS Medicinal Chemistry Letters

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders

Satoru Noji, Yoshinori Hara, Tomoya Miura, +17

Journal of Medicinal Chemistry

Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: Benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety

Shintaro Hirashima, Takahiro Oka, Kazutaka Ikegashira, +10

Bioorganic & Medicinal Chemistry Letters

Biochemistry2-Morpholinophenyl MoietyNatural SciencesAntiviral Drug DevelopmentAntiviral Therapy +6

Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold

Masayuki Kotoku, Takaki Maeba, Shingo Fujioka, +21

Journal of Medicinal Chemistry

Butanoic Acid ScaffoldImmunologyChemical BiologyPharmaceutical ChemistryInflammation +18