Orphagen Pharmaceuticals (United States)

SAR Exploration Guided by LE and Fsp ³ : Discovery of a Selective and Orally Efficacious RORγ Inhibitor

Kazuyuki Hirata, Masayuki Kotoku, Noriyoshi Seki et al. · ACS Medicinal Chemistry Letters · 2015 · 59 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold

Masayuki Kotoku, Takaki Maeba, Shingo Fujioka et al. · Journal of Medicinal Chemistry · 2019 · 31 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Ternary complex of human <scp>ROR</scp>γ ligand‐binding domain, inverse agonist and <scp>SMRT</scp> peptide shows a unique mechanism of corepressor recruitment

Masato Noguchi, Akihiro Nomura, Ken Murase et al. · Genes to Cells · 2017 · 28 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction

Masato Noguchi, Akihiro Nomura, Satoki Doi et al. · Scientific Reports · 2018 · 18 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17