Shintaro Hirashima

Benzimidazole Derivatives Bearing Substituted Biphenyls as Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase Inhibitors:  Structure−Activity Relationship Studies and Identification of a Potent and Highly Selective Inhibitor JTK-109

Shintaro Hirashima, Takayoshi Suzuki, Tomio Ishida et al. · Journal of Medicinal Chemistry · 2006 · 149 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: Identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole

Tomio Ishida, Takayoshi Suzuki, Shintaro Hirashima et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 130 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Discovery of Conformationally Constrained Tetracyclic Compounds as Potent Hepatitis C Virus NS5B RNA Polymerase Inhibitors

Kazutaka Ikegashira, Takahiro Oka, Shintaro Hirashima et al. · Journal of Medicinal Chemistry · 2006 · 112 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

SAR Exploration Guided by LE and Fsp ³ : Discovery of a Selective and Orally Efficacious RORγ Inhibitor

Kazuyuki Hirata, Masayuki Kotoku, Noriyoshi Seki et al. · ACS Medicinal Chemistry Letters · 2015 · 59 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Convergent Approach to Pumiliotoxin Alkaloids. Asymmetric Total Synthesis of (+)-Pumiliotoxins A, B, and 225F

Sakae Aoyagi, Shintaro Hirashima, Kosuke Saito et al. · The Journal of Organic Chemistry · 2002 · 54 citations

Natural Sciences, Chemistry, Medicinal Chemistry +14