BMN 673, a Novel and Highly Potent PARP1/2 Inhibitor for the Treatment of Human Cancers with DNA Repair Deficiency

Yuqiao Shen, Farah Rehman, Ying Feng, +7

Clinical Cancer Research

Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity

Clodagh C. O’Shea, Leisa Johnson, Bridget Bagus, +11

Cancer Cell

Tumor BiologyMedicinePathologyTumor SuppressorCancer Biology +5

Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition

Junko Murai, Ying Feng, Guoying Karen Yu, +4

Oncotarget

Trapping Poly(ADP-Ribose) Polymerase

Yuqiao Shen, Mika Aoyagi-Scharber, Bing Wang

Journal of Pharmacology and Experimental Therapeutics

Dynamic variations in epithelial-to-mesenchymal transition (EMT), ATM, and SLFN11 govern response to PARP inhibitors and cisplatin in small cell lung cancer

C. Allison Stewart, Pan Tong, Robert J. Cardnell, +19

Oncotarget

PathologyCancer BiologyTumor BiologyOncologySclc Patient-derived Xenografts +15

Human cytomegalovirus IE1 and IE2 proteins are mutagenic and mediate “hit-and-run” oncogenic transformation in cooperation with the adenovirus E1A proteins

Yuqiao Shen, Hua Zhu, Thomas Shenk

Proceedings of the National Academy of Sciences

Proteomic Markers of DNA Repair and PI3K Pathway Activation Predict Response to the PARP Inhibitor BMN 673 in Small Cell Lung Cancer

Robert J. Cardnell, Ying Feng, Lixia Diao, +8

Clinical Cancer Research

Discovery and Characterization of (8<i>S</i>,9<i>R</i>)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1<i>H</i>-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3<i>H</i>-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent

Bing Wang, Daniel I. Chu, Ying Feng, +3

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyHeterocycle ChemistryChemical BiologyPharmaceutical Chemistry +17

Activation of the PI3K/mTOR Pathway following PARP Inhibition in Small Cell Lung Cancer

Robert J. Cardnell, Ying Feng, Seema Mukherjee, +10

PLoS ONE

Pi3k InhibitorsCell DeathCancer BiologyTumor BiologySignaling Pathway +14

Analyses of Single-Amino-Acid Substitution Mutants of Adenovirus Type 5 E1B-55K Protein

Yuqiao Shen, Galila Kitzes, Julie A. Nye, +2

Journal of Virology

Viral ReplicationMolecular BiologyAdenovirus Type 5Viral Structural ProteinVirus Structure +17