Mika Aoyagi-Scharber

Trapping Poly(ADP-Ribose) Polymerase

Yuqiao Shen, Mika Aoyagi-Scharber, Bing Wang · Journal of Pharmacology and Experimental Therapeutics · 2015 · 225 citations

Discovery and Characterization of (8<i>S</i>,9<i>R</i>)-5-Fluoro-8-(4-fluorophenyl)-9-(1-methyl-1<i>H</i>-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3<i>H</i>-pyrido[4,3,2-de]phthalazin-3-one (BMN 673, Talazoparib), a Novel, Highly Potent, and Orally Efficacious Poly(ADP-ribose) Polymerase-1/2 Inhibitor, as an Anticancer Agent

Bing Wang, Daniel I. Chu, Ying Feng et al. · Journal of Medicinal Chemistry · 2015 · 162 citations · Full text

Pharmaceutical Science, Pharmacotherapy, Heterocycle Chemistry +19

Neutral Endopeptidase-Resistant C-Type Natriuretic Peptide Variant Represents a New Therapeutic Approach for Treatment of Fibroblast Growth Factor Receptor 3–Related Dwarfism

Daniel J. Wendt, Melita Dvorak‐Ewell, Sherry Bullens et al. · Journal of Pharmacology and Experimental Therapeutics · 2015 · 118 citations

Delivery of an enzyme-IGFII fusion protein to the mouse brain is therapeutic for mucopolysaccharidosis type IIIB

Shih‐hsin Kan, Mika Aoyagi-Scharber, Steven Q. Le et al. · Proceedings of the National Academy of Sciences · 2014 · 117 citations · Full text

Structural basis for the inhibition of poly(ADP-ribose) polymerases 1 and 2 by BMN 673, a potent inhibitor derived from dihydropyridophthalazinone

Mika Aoyagi-Scharber, A.S. Gardberg, Bryan K. Yip et al. · Acta Crystallographica Section F Structural Biology Communications · 2014 · 54 citations · Full text

Potent Inhibitor, Molecular Biology, Chemical Biology +17