Homologs of the vancomycin resistance d-Ala-d-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function

Ivan A.D. Lessard, Steve D. Pratt, Dewey G. McCafferty, +5

Chemistry & Biology

Isolation, cloning, and expression of a 70-kilodalton plasminogen binding protein of Borrelia burgdorferi

Linden T. Hu, Steve D. Pratt, George Perides, +3

Infection and Immunity

Pathogen DetectionMolecular BiologyEscherichia ColiParasite GenomicsTick-borne Disease +14

Analysis of the humoral response to the flagellin protein of Borrelia burgdorferi: cloning of regions capable of differentiating Lyme disease from syphilis

Jeyashakila Robinson, Steve D. Pratt, Chirag B. Patel, +2

Journal of Clinical Microbiology

ImmunologyEscherichia ColiLyme DiseaseTick-borne DiseaseSerologic Testing +15

Synthesis and SAR study of acridine, 2-methylquinoline and 2-phenylquinazoline analogues as anti-prion agents

Hannah Cope, Roger Mutter, William P. Heal, +4

European Journal of Medicinal Chemistry

2-Phenylquinazoline AnaloguesMedicineSar StudyOrganic ChemistryChemistry +6

Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase

John G. Mina, Yôko Okada, N. K. Wansadhipathi-Kannangara, +6

Plant Molecular Biology

Plant Molecular BiologyBiosynthesisBiochemistryNatural SciencesMolecular Biology +4

Utility of Large-Scale Transiently Transfected Cells for Cell-Based High-Throughput Screens to Identify Transient Receptor Potential Channel A1 (TRPA1) Antagonists

Jun Chen, Marc Lake, Reza S. Sabet, +13

SLAS DISCOVERY

Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design

Adrian D. Hobson, Russell A. Judge, Ana L. Aguirre, +33

Journal of Medicinal Chemistry

Pharmaceutical ScienceDrug TargetLead IdentificationChemical BiologyPharmaceutical Chemistry +15

Novel AntibacterialClass

Peter J. Dandliker, Steve D. Pratt, Angela M. Nilius, +23

Antimicrobial Agents and Chemotherapy

Substrate requirements for ErmC' methyltransferase activity

Ping Zhong, Steve D. Pratt, Rohinton Edalji, +4

Journal of Bacteriology

Molecular BiologyEscherichia ColiChemical BiologyProtein SynthesisDrug Resistance +15

Novel inhibitors of bacterial protein synthesis: structure–activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants

Richard F. Clark, Sanyi Wang, Zhenkun Ma, +18

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAntimicrobial Drug DiscoveryBioorganic ChemistryPosition 3Biochemistry +9