L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-<i>t</i>-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

John W. Gillard, A W Ford‐Hutchinson, Chi-Chung Chan, +25

Canadian Journal of Physiology and Pharmacology

Cyclooxygenase-2 Inhibitors. Synthesis and Pharmacological Activities of 5-Methanesulfonamido-1-indanone Derivatives

Chun‐Sing Li, W. Cameron Black, Chi-Chung Chan, +6

Journal of Medicinal Chemistry

Medicinal ChemistryAnti-inflammatoryActive Cox-2 InhibitorHeterocyclicBiochemistry +12

Synthesis and biological evaluation of both enantiomers of L-761,000 as inhibitors of cyclooxygenase 1 and 2

Y. LEBLANC, W. Cameron Black, Chi-Chung Chan, +20

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBiochemistryMedicinePharmacotherapyCyclooxygenase 1 +6

Reduction of animal usage by serial bleeding of mice for pharmacokinetic studies: application of robotic sample preparation and fast liquid chromatography–mass spectrometry

Kevin P. Bateman, Geneviève Castonguay, Lijing Xu, +4

Journal of Chromatography B Biomedical Sciences and Applications

Animal UsageMedicineBioanalysisMass SpectrometryLaboratory Medicine +9

SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor

Y. LEBLANC, Patrick Roy, S. Boyce, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryAnti-inflammatoryActive Cox-2 InhibitorHealth SciencesMedicine +9

3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility

W. Cameron Black, Christine Brideau, Chi-Chung Chan, +12

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural SciencesMedicineSelective Inhibitors +4

Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class

Nathalie Ouimet, Chi-Chung Chan, S. Charleson, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryHeterocyclicBiochemistryFlosulide ClassMedicine +9

A selective inhibitor of cyclooxygenase-2 reverses endotoxin-induced pyretic responses in non-human primates

Chi-Chung Chan, Mary Panneton, Anne Marie Taylor, +2

European Journal of Pharmacology

InflammationAllergyMedicineSelective InhibitorToxicology +7

Thiopyrano[2,3,4-cd]indoles as 5-Lipoxygenase Inhibitors: Synthesis, Biological Profile, and Resolution of 2-[2-[1-(4-Chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic Acid

John H. Hutchinson, Denis Riendeau, Christine Brideau, +6

Journal of Medicinal Chemistry

Effects of two novel inhibitors of 5-lipoxygenase, L-651,392 and L-651,896, in a guinea-pig model of epidermal hyperproliferation

Chi-Chung Chan, Lucie Dubois, Vivien Young

European Journal of Pharmacology

OxysterolEpidermal HyperproliferationMedicineLipid PeroxidationNovel Inhibitors +5