Chi-Chung Chan

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-<i>t</i>-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

John W. Gillard, A W Ford‐Hutchinson, Chi-Chung Chan et al. · Canadian Journal of Physiology and Pharmacology · 1989 · 328 citations

Cyclooxygenase-2 Inhibitors. Synthesis and Pharmacological Activities of 5-Methanesulfonamido-1-indanone Derivatives

Chun‐Sing Li, W. Cameron Black, Chi-Chung Chan et al. · Journal of Medicinal Chemistry · 1995 · 71 citations · Full text

Medicinal Chemistry, Anti-inflammatory, Active Cox-2 Inhibitor +14

Synthesis and biological evaluation of both enantiomers of L-761,000 as inhibitors of cyclooxygenase 1 and 2

Y. LEBLANC, W. Cameron Black, Chi-Chung Chan et al. · Bioorganic & Medicinal Chemistry Letters · 1996 · 68 citations

Molecular Pharmacology, Biochemistry, Medicine +8

Reduction of animal usage by serial bleeding of mice for pharmacokinetic studies: application of robotic sample preparation and fast liquid chromatography–mass spectrometry

Kevin P. Bateman, Geneviève Castonguay, Lijing Xu et al. · Journal of Chromatography B Biomedical Sciences and Applications · 2001 · 51 citations

Animal Usage, Medicine, Bioanalysis +11

SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor

Y. LEBLANC, Patrick Roy, S. Boyce et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 45 citations · Full text

Medicinal Chemistry, Anti-inflammatory, Active Cox-2 Inhibitor +11