Charles E. Nichols

Binding of the Second Generation Non-nucleoside Inhibitor S-1153 to HIV-1 Reverse Transcriptase Involves Extensive Main Chain Hydrogen Bonding

Jingshan Ren, Charles E. Nichols, Louise E. Bird et al. · Journal of Biological Chemistry · 2000 · 121 citations · Full text

Crystal Structure, Viral Replication, Biochemistry +14

Structures, functions and adaptations of the human LINE-1 ORF2 protein

Eric T. Baldwin, Trevor van Eeuwen, David Hoyos et al. · Nature · 2023 · 107 citations · Full text

Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases

Jingshan Ren, Charles E. Nichols, Philip P. Chamberlain et al. · Journal of Medicinal Chemistry · 2007 · 66 citations

Inhibitor Complexes, Molecular Biology, Antiviral Drug +19

Structural insights into mechanisms of non‐nucleoside drug resistance for HIV‐1 reverse transcriptases mutated at codons 101 or 138

Jingshan Ren, Charles E. Nichols, Anna Stamp et al. · FEBS Journal · 2006 · 55 citations · Full text

Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition

Eric T. Baldwin, Matthias Götte, Egor P. Tchesnokov et al. · Proceedings of the National Academy of Sciences · 2022 · 37 citations · Full text

Crystal Structure, Viral Replication, Viral Polymerase Mechanism +18