Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

J Hayashi, Shigeo Ohta, Azusa Kikuchi, +3

Proceedings of the National Academy of Sciences

Mitochondrial DysfunctionGeneticsPathologyMolecular BiologyMolecular Genetics +16

Angiotensinogen-deficient mice with hypotension.

Keiji Tanimoto, Fumihiro Sugiyama, Y. Goto, +5

Journal of Biological Chemistry

HypertensionDevelopmental BiologyAngiogenesisCardiovascular DiseaseSodium Homeostasis +13

Human mitochondria and mitochondrial genome function as a single dynamic cellular unit.

Jun-Ichi Hayashi, Masakazu Takemitsu, Y. Goto, +1

The Journal of Cell Biology

GeneticsMolecular BiologyMolecular GeneticsMitochondrial BiologyRedox Biology +20

Effects of an aldose reductase inhibitor, epalrestat, on diabetic neuropathy. Clinical benefit and indication for the drug assessed from the results of a placebo-controlled double-blind study

Y. Goto, Norio Hotta, Y. Shigeta, +2

Biomedicine & Pharmacotherapy

Diabetes ManagementMedicineDiabetesDiabetic NeuropathyPharmacotherapy +5

Functional and morphological abnormalities of mitochondria in human cells containing mitochondrial DNA with pathogenic point mutations in tRNA genes.

J Hayashi, Shigeo Ohta, Y Kagawa, +7

Journal of Biological Chemistry

MitophagyMorphological AbnormalitiesGeneticsMolecular BiologyPathology +17

Accumulation of mtDNA with a Mutation at Position 3271 in tRNALeu(UUR) Gene Introduced from a Melas Patient to HeLa Cells Lacking mtDNA Results in Progressive Inhibition of Mitochondrial Respiratory Function

J Hayashi, Shigeo Ohta, Daiya Takai, +4

Biochemical and Biophysical Research Communications

ChromatinGenome InstabilityMitochondrial FunctionNatural SciencesGenetics +9

The Induction of Cell Differentiation and Polarity of Tracheal Epithelium Cultured on the Amniotic Membrane

Y. Noguchi, Y Uchida, Tetsuya Endo, +8

Biochemical and Biophysical Research Communications

Embryo CultureTracheal Epithelium CulturedDevelopmental BiologyCell SpecializationAmniotic Membrane +10

Arteriovenous oximeter for O2 content difference, O2 saturations, and hemoglobin content

Hiroyuki Suga, Shiho Futaki, Yuichi Ohgoshi, +2

American Journal of Physiology-Heart and Circulatory Physiology

Arteriovenous OximeterOxidative StressBlood FlowThrombosisO2 Content Difference +20

Hemorrheological Effects of Colloidal Plasma Substitutes Infusion A Comparative Study

Y. Goto, S. SAKAKURA, Mutsuko Hatta, +2

Acta Anaesthesiologica Scandinavica

Comparison between the effects of treatment in vitro and in vivo with lipopolysaccharide on responsiveness of rat thoracic aorta.

Ko Takakura, Y. Goto, Shigeru Kigoshi, +1

PubMed

MechanobiologyCardiovascular ToxicityHeart FailureRat Thoracic AortaCardiovascular Disease +11