Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic

Youn‐Bok Lee, Han-Jou Chen, João Peres, +17

Cell Reports

Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes

Danielle C. Diaper, Yoshitsugu Adachi, Ben Sutcliffe, +11

Human Molecular Genetics

GeneticsSynaptic TransmissionMotor ControlLoss-of-function PhenotypesSocial Sciences +14

A feedback loop between dipeptide-repeat protein, TDP-43 and karyopherin-α mediates C9orf72-related neurodegeneration

Daniel A. Solomon, Alan Stepto, Wing Hei Au, +21

Brain

GeneticsDipeptide-repeat ProteinSynaptic SignalingSocial SciencesFeedback Loop +17

Drosophila TDP-43 dysfunction in glia and muscle cells cause cytological and behavioural phenotypes that characterize ALS and FTLD

Danielle C. Diaper, Yoshitsugu Adachi, Luke Lazarou, +11

Human Molecular Genetics

Neurodegenerative DiseasesMuscle CellsDevelopmental BiologyDrosophila Tdp-43 DysfunctionDrosophila Tdp-43 +11

C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity

Youn‐Bok Lee, Pranetha Baskaran, Jorge Gomez-Deza, +12

Human Molecular Genetics

Key RoleGeneticsMolecular BiologyOther DprsIntronic Ggggcc +16

TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophila

Lies Vanden Broeck, Marina Naval-Sánchez, Yoshitsugu Adachi, +11

Cell Reports

Conserved cis-regulatory modules mediate complex neural expression patterns of the eyeless gene in the Drosophila brain

Yoshitsugu Adachi, Bernd Hauck, Jason Clements, +8

Mechanisms of Development

Eyeless GeneMolecular NeuroscienceDevelopmental BiologyDrosophila BrainMedicine +8

A conserved nuclear receptor, Tailless, is required for efficient proliferation and prolonged maintenance of mushroom body progenitors in the Drosophila brain

Mitsuhiko Kurusu, Yasushi Maruyama, Yoshitsugu Adachi, +3

Developmental Biology

BiologyDevelopmental BiologyDrosophila BrainCell DivisionMedicine +7

Cross-regulatory protein–protein interactions between Hox and Pax transcription factors

Serge Plaza, Frédéric Prince, Yoshitsugu Adachi, +3

Proceedings of the National Academy of Sciences

Dimer formation via the homeodomain is required for function and specificity of Sex combs reduced in Drosophila

Dimitrios K. Papadopoulos, Kassiani Skouloudaki, Yoshitsugu Adachi, +2

Developmental Biology

BiologyPattern FormationDevelopmental BiologyMedicineGenetics +8