CYP2C9 Ile359 and Leu359 variants: enzyme kinetic study with seven substrates

Kenji Takanashi, Hitoshi Tainaka, Kaoru Kobayashi, +3

Pharmacogenetics

Leu359 VariantBiochemistryMedicineEnzyme Kinetic StudyNatural Sciences +11

Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastases

Tatsushi Kodama, Masami Hasegawa, Kenji Takanashi, +3

Cancer Chemotherapy and Pharmacology

Neuro-oncologyOncologyAntitumor ActivityMedicineIntracranial Metastases +4

Design and synthesis of a highly selective, orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)

Kazutomo Kinoshita, Kohsuke Asoh, Noriyuki Furuichi, +11

Bioorganic & Medicinal Chemistry

Chemoprevention StrategyMedicineAnti-cancer AgentPharmacologyRadiation Oncology +1

9-Substituted 6,6-Dimethyl-11-oxo-6,11-dihydro-5<i>H</i>-benzo[<i>b</i>]carbazoles as Highly Selective and Potent Anaplastic Lymphoma Kinase Inhibitors

Kazutomo Kinoshita, Takamitsu Kobayashi, Kohsuke Asoh, +14

Journal of Medicinal Chemistry

Compound 13DMolecular PharmacologyMedicinal ChemistryHigh Target SelectivityMedicine +10

Prediction of Drug-Drug Interactions based on Time-Dependent Inhibition from High Throughput Screening of Cytochrome P450 3A4 Inhibition

Nobuo Sekiguchi, Atsuko Higashida, Motohiro Kato, +5

Drug Metabolism and Pharmacokinetics

Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties

Ikumi Hyohdoh, Noriyuki Furuichi, Toshihiro Aoki, +16

ACS Medicinal Chemistry Letters

EngineeringChemical AnalysisLead IdentificationOrganic ChemistryChemistry +21

Discovery of an Orally-Active Nonsteroidal Androgen Receptor Pure Antagonist and the Structure-Activity Relationships of Its Derivatives

Kazutaka Tachibana, Ikuhiro Imaoka, Takuya Shiraishi, +13

Chemical and Pharmaceutical Bulletin

Androgen Receptor-5,5-Dimethylthiohydantoin DerivativesOrganic ChemistryPharmacotherapyHeterocycle Chemistry +18

The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors

Toshihiro Aoki, Ikumi Hyohdoh, Noriyuki Furuichi, +13

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryOral BioavailabilitySulfamide Moiety AffordsBiochemistryMedicine +8

Analysis of surface composition and internal structure of fly ash particles using an ion and electron multibeam microanalyzer

Tetsuo Sakamoto, Ko Shibata, Kenji Takanashi, +2

Applied Surface Science

Materials ScienceInternal StructureChemical EngineeringEngineeringSurface Science +6

Metabolites of alectinib in human: their identification and pharmacological activity

Mika Sato-Nakai, Kosuke Kawashima, Toshito Nakagawa, +7

Heliyon