Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

Andrea Piunti, Rintaro Hashizume, Marc A. Morgan, +14

Nature Medicine

Neuro-oncologyNovel TherapyGliomaMedicinePathology +9

Enhancer-associated H3K4 monomethylation by Trithorax-related, the <i>Drosophila</i> homolog of mammalian Mll3/Mll4

Hans-Martin Herz, Man Mohan, Alexander S. Garruss, +6

Genes & Development

Histone ModificationsHistone H3Epigenetic ChangeGeneticsGenomic Mechanism +19

Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom)

Man Mohan, Hans-Martin Herz, Yoh-hei Takahashi, +6

Genes & Development

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

Ryan Rickels, Hans-Martin Herz, Christie C. Sze, +16

Nature Genetics

Histone ModificationsChromatinTranscriptional RegulationChromatin RemodelingMedicine +12

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

Lu Wang, Zibo Zhao, Patrick A. Ozark, +16

Nature Medicine

Cancer TherapyChromatinChromatin RemodelingEpigenetic ChangeEpigenomics +8

Structural analysis of the core COMPASS family of histone H3K4 methylases from yeast to human

Yoh-hei Takahashi, Gerwin Westfield, Austin N. Oleskie, +3

Proceedings of the National Academy of Sciences

Histone ModificationsEpigenetic ChangeCompass Family MembersMolecular BiologyMolecular Genetics +20

Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory

Agustina D’Urso, Yoh-hei Takahashi, Bin Xiong, +6

eLife

Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex

Qianhui Qu, Yoh-hei Takahashi, Yidai Yang, +6

Cell

Histone ModificationsChromatinConformational DynamicsChromatin StructureChromatin Remodeling +11

Dot1 and Histone H3K79 Methylation in Natural Telomeric and HM Silencing

Yoh-hei Takahashi, Julia M. Schulze‐Hentrich, Jessica Jackson, +5

Molecular Cell

Histone ModificationsChromatinGenome InstabilityHm SilencingChromatin Structure +12

Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia

Yalu Zhou, Cuijuan Han, Eric Wang, +41

Cancer Discovery